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04-21-2011, 07:51 AM | #1 | |||
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In Remembrance
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First of all, how could it not be? Second, the antibodies were found in older PWP but not younger?? Twenty years ago....
1. Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(6):7-11. [Dopamine antibodies in parkinsonism patients and their possible role in the pathogenesis of the parkinsonian syndrome]. [Article in Russian] Man'kovskiĭ NB, Karaban' IN, Kryzhanovskiĭ GN, Evseev VA, Magaeva SV, Vetrila LA, Trekova NA, Basharova LA, Golubev KM. Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients, middle-aged and elderly, but not young. There was a correlation between the DAb incidence and dominant symptom in the middle-aged and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (the generator of pathologically enhanced excitation-GPEE) in this brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity and tremor). This effect was more expressed in the elderly rats compared with the young animals. The DAb role in the Parkinson's syndrome pathogenesis and in L-DOPA therapeutic tolerance formation is discussed. PMID: 7512781 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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