Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 05-13-2011, 10:37 AM #1
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,858
10 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,858
10 yr Member
Default Estrogen receptors play anti-inflammatory role in the brain

Estrogen receptors play anti-inflammatory role in the brain

http://www.eurekalert.org/pub_releas...-erp050911.php

Researchers have uncovered an unexpected role for estrogen receptors in the brain in keeping inflammation under control. The findings reported in the May 13 issue of the Cell Press journal Cell may have important implications for the treatment of multiple sclerosis (MS) and many other neurodegenerative diseases. They might also help to explain why women are three times more susceptible to developing MS than men are, researchers say...


Estrogen receptors are primarily known to activate programs of gene expression, he explained. In this case, however, estrogen receptors are critical for turning off genes that would otherwise lead to chronic inflammation...

The estrogen receptor (ER)... (is) related receptors known as ERβ found in cells of the brain known as microglia and astrocytes. Microglia serve as sentinels of infection and injury in the brain... astrocytes also sense infection and injury, and amplify the immune reaction initiated by microglia.


When levels of either ADIOL or ERβ were experimentally reduced, cells and animals showed an exaggerated inflammatory response...

Although MS is a very complicated disease, the findings suggest drugs targeted at the ERβ receptors might effectively shut down the inflammation... The same principle might also work in the treatment of other neurodegenerative conditions associated with inflammation, including Parkinson's, Alzheimer's and HIV-associated dementia.

The findings might also help to explain the strong sex bias in MS, which disproportionately affects relatively young women...



In addition to explaining why females develop MS more often than males, Gosselin and Rivest continued, the findings also suggest that birth control medications and environmental factors such as estrogen analogs derived from plants might also promote development of the disease.

"The possibility arises from our study that estradiol can antagonize the anti-inflammatory effects of ADIOL," Glass said. "This may lead to a shift in the balance from anti-inflammatory to inflammatory."

Glass and Saijo say they plan to further explore the role of this pathway in other neurodegenerative diseases..
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote

advertisement
Old 05-13-2011, 10:46 AM #2
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,858
10 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,858
10 yr Member
Default another report of findings

another report of the findings:

http://tinyurl.com/3w9lqnk

http://www.domainb.com/technology/bi...lammation.html
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote
Old 05-13-2011, 10:56 AM #3
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
10 yr Member
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
10 yr Member
Default Madelyn

Does this finding mean estrogen as we know it could help postmenopausal pwp? or young onset menopause?

i know my hormones were involved somehow.

thanks
__________________
paula

"Time is not neutral for those who have pd or for those who will get it."
paula_w is offline   Reply With QuoteReply With Quote
Old 05-13-2011, 04:51 PM #4
olsen's Avatar
olsen olsen is offline
Senior Member
 
Join Date: Aug 2006
Posts: 1,858
10 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,858
10 yr Member
Default estrogen replacement

Hi Paula, my honest answer is "I have no idea". wonder if contacting one of the researchers for this study would help in obtaining at least a clue to whether estrogen replacement would help. best to you, madelyn
__________________
In the last analysis, we see only what we are ready to see, what we have been taught to see. We eliminate and ignore everything that is not a part of our prejudices.

~ Jean-Martin Charcot


The future is already here it's just not very evenly distributed. William Gibson
olsen is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
VICTORIALOU (05-14-2011)
Old 05-14-2011, 01:40 PM #5
VICTORIALOU's Avatar
VICTORIALOU VICTORIALOU is offline
Member
 
Join Date: Oct 2010
Location: Los Angeles area
Posts: 240
10 yr Member
VICTORIALOU VICTORIALOU is offline
Member
VICTORIALOU's Avatar
 
Join Date: Oct 2010
Location: Los Angeles area
Posts: 240
10 yr Member
Default

Quote:
Originally Posted by olsen View Post
Hi Paula, my honest answer is "I have no idea". wonder if contacting one of the researchers for this study would help in obtaining at least a clue to whether estrogen replacement would help. best to you, madelyn
Intuitively, I have also been aware of an estrogen connection.
It is interesting that one of the worst side effects of all the plastics we are exposed to is that those plastic residues act to mimic estrogen in the estrogen receptors. http://www.npr.org/2011/03/04/134240...genic-activity
VICTORIALOU is offline   Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Protective Effects of Estrogen and Selective Estrogen Receptor Modulators in th Brain lou_lou Parkinson's Disease 0 12-14-2009 12:36 PM
MIT Unlocks Mystery Behind Brain Imaging Star-Shaped Brain Cells Shown/Play Key Role Stitcher Parkinson's Disease 0 06-19-2008 06:30 PM


All times are GMT -5. The time now is 11:31 AM.

Powered by vBulletin • Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.