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05-20-2011, 06:38 PM | #1 | ||
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Clinical PD subtypes: tremor-dominant and postural-instability-gait-difficulty (PIGD)
My only complain is severe tremor which is not helped by l-dopa.
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Imad Born in 1943. Diagnosed with PD in 2006. |
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05-21-2011, 07:29 AM | #2 | |||
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In Remembrance
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http://www.ncbi.nlm.nih.gov/sites/en...ranolol+tremor
I don't have much problem with tremor, so I'm not in a position to try it for that purpose. However, I am taking the same drug for hypertension and to control the potassium shift problem that I have described elsewhere on this forum. Propranolol works by blocking the receptors for the stress hormones generated by our adrenals. It is a very old drug and long out of patent. I think it is very much under-utilized in the PD battle.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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"Thanks for this!" says: | imark3000 (05-21-2011) |
05-21-2011, 06:22 PM | #3 | ||
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I found follwing article which suggests some medicines including Beta blocker Propranol.The problem: my neuro did not recognise any thing for me apart from sinemet.
Tremor-predominant Parkinson's disease. Approaches to treatment.Marjama-Lyons J, Koller W. SourceDepartment of Neurology, University of Florida, Jacksonville, USA. jm.lyons@jax.ufl.edu Abstract Parkinson's disease is a neurodegenerative disorder that manifests clinically with variable degrees of tremor, muscle rigidity, bradykinesia and postural instability. Tremor-predominant Parkinson's disease is characterised by prominent tremor of one or more limbs with a relative lack of significant rigidity and bradykinesia. Despite the lack of other disabling motor symptoms, the tremor of tremor-predominant Parkinson's disease can be very disabling, especially if a postural and kinetic component exists. A wide variety of treatments for Parkinson's disease tremor are currently available and include use of oral medications, injections with botulinum toxin and neurosurgical procedures. Some of the first line medications (levodopa, dopamine agonists, anticholinergics) are very effective in controlling tremor. However, some patients with Parkinson's disease tremors are unresponsive to first line drugs and treatment with second line medications (clozapine, amantadine, clonazepam, propranolol, neurontin) should be attempted. In the small number of patients with disabling tremor that is refractory to all medications, neurosurgical intervention should be considered. Both thermocoagulation and deep brain stimulation at several different neuroanatomical sites (thalamus, globus pallidus, subthalamic nucleus) offer good to excellent tremor control with relatively low risk to the patient.
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Imad Born in 1943. Diagnosed with PD in 2006. |
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"Thanks for this!" says: | budgies (05-22-2011) |
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