[reverett123]

I know that this was touched on briefly a few weeks ago, but this first quote got my attention-

From http://www.newscientist.com/article/...arkinsons.html
"A FEW years ago, John Gillies had trouble picking up his grandchild. He would stand frozen, waiting for his Parkinson's disease to relinquish its hold and allow him to move. Then in May 2008, Gillies was given antibiotics to treat constipation, and astonishingly his Parkinson's symptoms abated. What on earth was going on?

Thomas Borody, a gastroenterologist at the Centre for Digestive Diseases in New South Wales, Australia, put Gillies on antibiotics because he had found that constipation can be caused by an infection of the colon. "He has now been seen by two neurologists, who cannot detect classic Parkinson's disease symptoms any more," says Borody. "


There is further coverage at http://www.choicepointmagazine.com/node/46

This ties in rather nicely with the "anecdotes" of PWP who experienced temporary relief when they were given a course of antibiotics for unrelated reasons.

[madamlash]

Originally Posted by reverett123

I know that this was touched on briefly a few weeks ago, but this first quote got my attention-

From http://www.newscientist.com/article/...arkinsons.html
"A FEW years ago, John Gillies had trouble picking up his grandchild. He would stand frozen, waiting for his Parkinson's disease to relinquish its hold and allow him to move. Then in May 2008, Gillies was given antibiotics to treat constipation, and astonishingly his Parkinson's symptoms abated. What on earth was going on?

Thomas Borody, a gastroenterologist at the Centre for Digestive Diseases in New South Wales, Australia, put Gillies on antibiotics because he had found that constipation can be caused by an infection of the colon. "He has now been seen by two neurologists, who cannot detect classic Parkinson's disease symptoms any more," says Borody. "


There is further coverage at http://www.choicepointmagazine.com/node/46

This ties in rather nicely with the "anecdotes" of PWP who experienced temporary relief when they were given a course of antibiotics for unrelated reasons.

It would be great to know exactly what antibiotic Thomas Borody prescribed.

[reverett123]

One of the "anecdotes" used "Penicillin VK" but it might depend on the bacteria.

[villiers]

My personnal view on this is that PD is definitely linked to a poor imbalance between gut flora and yeast........yeast infection can definitely lead to big Neuro problems.......and antibiotics can kill,but only temporarly,yeast infection

you should google "candida & dopamine"
quite a few interestings things......

since a few months,i am on a very strict candida diet,plus yeast natural treatments plus loads of fiber & probiotics
My shaking is now less than two years ago !: )
some natural antifungal remedies are the same which have been proven to slow Pd !!

like turmeric,coconut oil,cinnamon.....



on an other blog i found this testimony :

My husband, 57, has had Parkinson's for almost 7 years, and we have recently noticed a decline in his physical condition (postural instability, balance issues, etc.) despite a regimen for many years of Mirapex, Azilect, etc. BUT the most amazing thing happened. As a result of extensive allergy testing through a very reputable lab, he showed a problem with yeast. His doctor put him on 10 days of Diflucan (150 mg). This 10 days was the FIRST time in years where he had much more energy, significantly-lessened tremors (he could eat without any shaking), no "lurching" when he walked, and no balance problems while walking. A few days after he stopped the Diflucan, his Parkinson's symptoms worsened once again. At that point, he doctor gave him 30 days of Diflucan (200 mg) to attack the yeast problem. Again, a VERY DRAMATIC improvement in his symptoms for the entire month. Within a week of ending the Diflucan, his symptoms, once again, are much worse. We understand that there are potential long-term liver issues with the use of this anti-fungal medication, but it is obvious that yeast is a BIG part of his problem. He said that his days on Diflucan were the FIRST time in the last 7 years that he has felt "better". Do you have any information about Candida worsening Parkinson's symptoms and how we can attack this piece of the puzzle? Thank you for your time and concern.

[reverett123]

1. Bratisl Lek Listy. 2006;107(6-7):227-30.

Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic
Parkinson's disease.

Epp LM, Mravec B.

Institute of Pathophysiology, Faculty of Medicine, Comenius University,
Bratislava, Slovakia.

The underlying cause of Parkinson's disease is still enigma. Several mechanisms
have been implicated in the etiopathogenesis of PD including oxidative damage,
environmental toxins, genetic predisposition, and accelerated aging. Recent
research suggests that salsolinol, a derivate of dopamine, is an important
contributing factor. In the presence of acetaldehyde dopamine is converted into
salsolinol, a neurotoxin involved in apoptosis of dopaminergic neurons. Increased
production of acetaldehyde is associated with chronic polysystemic candidiasis
(CPC). Chronically elevated levels of acetaldehyde in patients with CPC might
participate in the formation of salsolinol and its metabolites in the brain
contributing to the destruction of dopaminergic cells in substantia nigra.
Clinical mental symptoms of PD often correspond with the mental manifestations of
CPC. This hypothesis may constitute basis for further scientific and clinical
research of PD etiopathogenesis (Fig. 1, Ref. 29).


PMID: 17051898 [PubMed - indexed for MEDLINE]

[villiers]

an excerpt from the brilliant book "roads to recovery" by Robert Rodgers:

People with an overgrowth of Candida exhibit elevated levels of acetaldehyde in their gastro
intestinal track. Acetaldehyde is one of fifty different toxins that is produced by the Candida
organism. And you thought I was talking about a harmless pinch of yeast?
When concentrations of acetaldehyde become too high, the liver is no longer able to remove it
successfully. Acetaldehyde has no other choice than to hang around the tissues of the body
with a special preference for the brain.
What happens next comes as bad news for the nervous system. Acetaldehyde combines with
dopamine to synthesize a substance called Salsolinol. Hang on to your seats:
Salsolinol destroys dopaminergic cells in the substantia nigra. Internally manufactured by the
body, Salsolinol itself is a neurotoxin. Increased levels of salsolinol have been found in the
cerebral spinal fluid and the urine of people who have been diagnosed with Parkinsons.
The sequence of causal events is the following:
1. Candida produces acetaldehyde.
2. Acetaldehyde causes the synthesis of Salsolinol.
3. Salsolinol kills off the cells that produce dopamine.