See,

Levels of dopamine in blood and brain following nasal administration to rats
Maria Dahlin, Björn Jansson and Erik Björk, 2001

"The aim of this study was to investigate the levels of [3H]dopamine in blood, the cerebrospinal fluid (CSF) and brain tissue samples in rats and to find out whether the drug is transferred along the olfactory pathway to the central nervous system following nasal administration. ... In conclusion, these results show that unchanged dopamine is transferred into the olfactory bulb via the olfactory pathway in rats."

http://www.sciencedirect.com/science...28098701001518

John

Well it clearly works, and even with dopamine, which arrives at the target unchanged. When we think of the amount of levodopa which is lost via the oral method, (over 90%?) why isn't this route given more attention. Only a fraction of oral levodopa gets to the brain unchanged, and we use copious amounts, resulting in crushing dyskinesia. Not only that, but the effect would be nearly immediate via the nasal route, compared with the half hour to an hour we have to wait for the oral route to get there via the bloodstream
Big Pharma would not be interested, they would not sell anything like the tonnage used worldwide via the oral route. And no sales of amantadine to curb dyskinesia. I think we are going to have to fundraise and do the research ourselves.
Ron

Well, I was going to make something witty about bananas and vaporizers and scuba gear. Then I realized that even that wasn't completely off the wall.

Dopamine is water soluble so no nasty solvents. Should be easy to concentrate by evaporation. You see folks trundle around oxygen tanks, but you probably wouldn't need to go that far.

add a mucuna gene to the banana, dry the skins and smoke, sorted, as people say here in the uk

alternatively add mucuna and banana genes to tobacco, and we'd get neuroprotection too..... sorry couldn't resist!!