[imark3000]

This is not new and it may have been posted before. It seems promising. Any body following up this?


Dramatic Improvement in Parkinson Disease Symptoms Following Intranasal Delivery of Stem Cells to Rat Brains
ScienceDaily (Feb. 9, 2011) — Successful intranasal delivery of stem cells to the brains of rats with Parkinson disease yielded significant improvement in motor function and reversed the dopamine deficiency characteristic of the disease.

[lindylanka]

I guess Ron Hutton will know about this. He has been asking about intranasal delivery for so long that maybe he was the first to ever suggest it!

[imark3000]

Originally Posted by lindylanka

I guess Ron Hutton will know about this. He has been asking about intranasal delivery for so long that maybe he was the first to ever suggest it!

Lyndy,
This research has the signatures of a number of European universities, so I suppose it has certain credibility. Even though it is still rat tests but the claims are remarkable and wish that US or Canadian research would repeat and expedite the results.
I quote:
"In this groundbreaking study, mesenchymal stem cells (MSCs) delivered via the nose preferentially migrated to the brain and were able to survive for at least 6 months. Substantial improvement in motor function -- up to 68% of normal -- was reported in the MSC-treated rat model of Parkinson disease. Levels of the neurotransmitter dopamine were significantly higher in affected rat brain regions exposed to MSCs compared to the non-treated brain regions, reported Lusine Danielyan and an international team of researchers from University Hospital of Tübingen, University of Göttingen Medical School, and University of Tübingen (Stuttgart, Germany; HealthPartners Research Foundation, St. Paul, MN; German University in Cairo, Egypt; Harvard University, Cambridge, MA; Institute of Molecular Biology NAS RA, Yerevan, Armenia; and Geneva University Hospital, Switzerland.

The authors explain that intranasal delivery of MSCs avoids the tissue trauma and related inflammation and brain swelling associated with surgical implantation of therapeutic stem cells. Importantly, this noninvasive delivery method would also make it possible to provide repeated stem cell treatments over time."

[GregD]

I remember seeing this before. As I recall, there was a problem with it but I will have to do some research to tell what that problem was.

[imark3000]

Originally Posted by GregD

I remember seeing this before. As I recall, there was a problem with it but I will have to do some research to tell what that problem was.

Thank you Greg for your digging into the story. As usual there is a catch in any good news but we hope against hope!

Imad

[GregD]

Well as usual, I cannot locate the report I had read explaining problems with Intranasal Delivery of Stem Cells. I was sure I had saved it to my hard drive but I guess not and a search of the internet has not turned up anything. I will post if for you if I ever find it.

[imark3000]

Originally Posted by GregD

Well as usual, I cannot locate the report I had read explaining problems with Intranasal Delivery of Stem Cells. I was sure I had saved it to my hard drive but I guess not and a search of the internet has not turned up anything. I will post if for you if I ever find it.

Thank you GregD again. I find myself overwhelmed by too much information and my poor memory and loss of the capability for multitasking is certainly making things worse !
I often find my own post on the forum when I am searching an issue on google that I searched some time ago

[Ronhutton]

Originally Posted by lindylanka

I guess Ron Hutton will know about this. He has been asking about intranasal delivery for so long that maybe he was the first to ever suggest it!

Hi Lindy,
I don't think I was the first to suggest it, but I have been pushing it for over 10 years now. I persuaded a UK company to investigate it, but they did some work then dropped it. It is now fairly widely used for other diseases. One reseasrcher who has worked on it for over 10 years is William Frey. As he said, "If bad things get into the brain through the nose, lets use it to get good things in".
There is a passage from the nose to the brain called the intranasal passage. It by-passes the BBB, and you get immediate entry to the brain.
It is the reason why smokers get immediate satisfaction by inhaling through the nose. The nicotine gives a fast "high". They don't have to wait an hour for it to get into the blood stream, across the BBB and into the brain, as we do with orasl drugs. The same reason why drug users snort their cocaine etc. THey get an immediate high.
Do not try it on sinomet containing carbidopa, you don't want that in the brain. It does not pass the BBB so is safe orally. But in all this time an experiment putting dopamine or levodopa into a nasal spray does not seem to have been done.
Ron

[reverett123]

Just brainstorming here, but I wonder if a "vaporizer" of either the steam or cold variety would be of any use, perhaps in the sleeping environment.

Originally Posted by Ronhutton

Hi Lindy,
I don't think I was the first to suggest it, but I have been pushing it for over 10 years now. I persuaded a UK company to investigate it, but they did some work then dropped it. It is now fairly widely used for other diseases. One reseasrcher who has worked on it for over 10 years is William Frey. As he said, "If bad things get into the brain through the nose, lets use it to get good things in".
There is a passage from the nose to the brain called the intranasal passage. It by-passes the BBB, and you get immediate entry to the brain.
It is the reason why smokers get immediate satisfaction by inhaling through the nose. The nicotine gives a fast "high". They don't have to wait an hour for it to get into the blood stream, across the BBB and into the brain, as we do with orasl drugs. The same reason why drug users snort their cocaine etc. THey get an immediate high.
Do not try it on sinomet containing carbidopa, you don't want that in the brain. It does not pass the BBB so is safe orally. But in all this time an experiment putting dopamine or levodopa into a nasal spray does not seem to have been done.
Ron

[lindylanka]

Rick, I love the idea of constant delivery by vapour, but can't imagine how it would work in a busy home, as we need medicating by day not night.... but perhaps you have some thoughts on this. If something like this were a possibility and it could be managed with partners and family not getting od'ed on dopa it would give a constant dosing like duodopa, without the need for surgery, or would we need a nasal tube. Just thinking around the idea......