it's over two weeks from worldwide boadcast and noobody has commented on

http://www.newscientist.com/article/...arkinsons.html

This group of researchers in the UK, will probably be the first to cure PD and it WILL be done by cell manipuation. For too many years the "Dopaminergic CELL REPLACEMENT THERAPEUTIC APPROACH" to a PD cure has been put through the wringer and almost abandoned by everybody. BUT, that's what is going to make us walk away from this disease, nothing else!!!!!!!!!!!!!

People with Parkinson's disease might one day be treated with brain cells made from their own skin........

.......The studies raise the possibility of improving mobility in people with Parkinson's by restoring dopamine production to normal. At present, most patients take a drug called L-dopa to readjust levels, but with varying levels of success.

Both techniques avoid the initial step of converting skin cells into embryo-like pluripotent cells – a technique which poses a possible cancer risk.

many of us believe that this will not happen in our lifetime. I don't get excited over cell replacemet for that and other reasons.

it's as clear as mud, a cell based cure is on the cusp of reality, those fears were engendered by the Swedish studies done 30+ years ago. Just because they were giving undifferentiated human nigral neurons that metastetized, doesn't mean a thing. Look at the p series of enzymes that are now hot targets in cancer research. These things can be modified in ways so as to not "turn" on cancer cells, or to "turn" off the cancer producng penchant of any cell population. This is going to pan out, SOON!!!!!! cs

i'll keep fighting but when is soon?

but the brain is a good place to work in, the immune resonse is much lowered, but somehow those nasty snipets of dna that are responsible for the observed problems with neural tissue rejection or apoptosis will be solved. Those who are shooting for the prize know what they are doing, i don't. But the idea is so logical, only it's mechanisms remain elusive, and like most of the great advances in medicine , there will be a certain amount of serendipity involved with it. Have you noticed the trend in which "pharmaceutical giants" are now concentrating their efforts on "biopharmacy" which was prompted by recent trends that pointed to very large , protein like molecules having the ability to be totally elucidated, not just "globs of a factor that did something". With this revolution, the very heart of cellular function can be controlled. I give it before i'm dead TILL PD IS NO LONGER A FEARED HUMAN CONDITION. cs

Even if there was a risk of cancer there would still be PwP who would be prepared to take the chance.

I know this is artificial, but would you accept the following deal:
100% cure from PD, but after 5 cancer-free years a 10% chance of cancer per year.

Your answer will vary according to your age and progression etc..

John

I think most would go for it regardless of age because the thinking would be, heck, I get rid of PD now, and while I'm living a PD-free life they can work out the kinks for the cancer risk. And, if I get cancer, well, there is so much that can be done for cancer right now and there's a lot of lifestyle things that I've read have either nixed cancer completely or significantly altered its course...and who knows what treatments are in the works or will be out by the time my cancer, IF I get it, becomes a real issue.

Yes, it is interesting how drug companies have quietly been focusing more on botannicals and stem cell work....

Stem cell stuff seems to be working in non human models, I would like to know more about the pros and cons of such treatments, it always seems to me that scientists go into areas where angels fear to tread, and sometimes they win on behalf of people, but as often the downsides are only found out later, look at agonists, were though to be great idea, great technology to create drugs that would mimic, but it is only in long term human use that the real problems started to emerge. I know that we have to start somewhere with any idea, but I wish that the potential problems were discussed as much as the amazing 'cure' aspects.

Thinking of the closed down stem-cell facility in europe, and the major claims being made for all sorts of diseases that can be cured......