Well here we go again. I was doing good this morning, kept the meds on schedule. I was even able to do a little housework. Then I laid down for a nap at about 1 or so and got up at 4. I was off so I took a usual dose of sinemet 1 1/2 tabs. At 5:30 time for another dose-but I wasn't getting any relief from the previous dose. At about 6 pm I took another 1/2 tab. We went out for dinner and I was on, even a little dyskinetic, came home around 9:30 and was off. Now it is 5 in the morning and I've been up for 2 hours now. I'm bouncing around here so badly that I cannot even hold my head straight. The meds don't have an effect then they come on like they have piled up. This is really aggravating, depressing, frustrating all at once. And the thing is I know that there are other treatments that are better at stabilizing the doseage-duodopa, yet it's not out yet. And at what point is it made available to someone who has had DBS but it was not very effective. Neuro appt August 1. We gotta talk.