Hello,

In February, my neurologist prescribed me Zoloft for depression. That evening I stopped taking Selegiline and began taking Zoloft. Within a few days, my PD meds(Sinemet and Requip) weren't working anymore. I "froze up" from head to toe. My eyes were even stiff. Also, my lower spine felt paralyzed, numb. After 3 weeks of this, it started getting better because my medication was becoming effective again. (Although, the effectiveness of the generic of Sinemet has declined considerably in the past few months. But this seems to be a wide-spread problem among many PWP.) But, since I first starting taking Zoloft(stopped after 4 days) and when I'm "off", I still become very stiff, especially in my lower spine.

Also since taking Zoloft, my eyes(eyeballs) have changed and feel stiff and the lids feel heavy and tend to go down easily. I can't focus well during this. Weird!

I'm wondering if anyone has had a mild case of Serotonin Syndrome and can fill me in on their symptoms and if it got better or worse. And, did it cause the Parkinson's to progress? I've read about the syndrome and did have more than 3 of the symptoms. I feel like a walking zombie during my "off" times, which are too often.

Another weird thing is I'm allergic to the generic of Sinemet. I was able to tolerate Mylan's generic, no allergies. But, the pharmacies can't get it anymore. I've tried Teva's, Purepac's and Actavis' generics. I've had a bad reaction to all three; burning in mouth, on tongue and down throat, sometimes bleeds, and I cough up a dark fluid from my lungs about 45 mins. to an hour after taking it. I know it is probably a binding agent that I'm allergic to. Anyone else having this problem? And, would Stalevo or Amantadine be a good substitute for Sinemet? I hate to think that I can't take carb/levo or Sinemet anymore. I have cut back on my Requip intake by 5 mg and it has made getting around quite challenging.

Any advice is appreciated. I am actively looking for a solution to get better. Aren't we all?!

Thanks in advance for replying!
Tonya