My PD history started 14 years ago. It was mainly tremor. First it was left side tremor. Now it is also the right side. For years now I have been taking Stalevo, Requip, Azilect, Artane, Prolopa and Q10. I am quite comfortable with these drugs, except Artane which does not seem to help a lot and seems to decrease my memory capacity. The combination above causes involuntary movements especially when Stalevo and Prolopa act together. My Neuro proposes Amantadine. I am personally worried about its possible side effects. Please is there anyone who has experience with Amantadine? Does it fight against involontary movements and tremor? Has anyone replaced any drug with Amantadine? All input will ve highly appreciated. Thanks.

I have been diagnosed with PD for twelve years now. I was prescribed Amantadine two years into it to help with tremor. For me, the Amantadine did nothing for the tremor so after a year it was stopped. As I recall the only side effects were a red blotchy look or molting of the ankles and lower legs which is nothing to worry about and swelling of the feet. Other than that, Amantadine was originally used as a flu medication. I did not get sick during the time I was taking it. It does work quite well for some people. Give it a try and see.

My wife was also diagnosed with PD 14 years ago. She was taking Sinemet, Lodosyn, Amantadine, and Mirapex before she was accepted into the intestinal gel study.

Mirapex and Amandadine both have hallucination as known side effects. My wife suffered greatly with them for years but since being removed off these two drugs due to the gel she has had no hallucination issues at all. Zero. A huge thing, they were a torment for her both during the night and into the day as well.

Hope this helps.

In the early years I suffered considerably from micro-somnia and hallucinations due to Requip. These gradually disappeared. Now I am suffering from swollen feet again because Requip, but this is a minor issue which I can cope with. I am greatly obliged to anyone who can write about his/her experience with Amantadine.

My neuro tried Amantidine on me six months ago with the warning that it should be stopped immediately at the first sign of depression as it can (rarely) escalate quickly to suicide. I did experience a hint of such and quit.

I've taken amantadine for almost the full 10 years I have been diagnosed with PD, along with sinemet and antidepressants (currently welbutrin and cymbalta). A couple of months after starting out with 200 mg amantadine, my feet and ankles swelled rather badly. Backing off to 100 mg resulted in the swelling going away. I still have some "purple blotchies", especially in cold weather. No other side effects from amantadine that I am aware of.