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Certain Movements Make Me Better

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Old 08-11-2011, 11:38 AM   #1
I_Got_it_2
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Default Certain Movements Make Me Better

Hi there. As my login name says, I got it too. Parkinson's, that is. This is my first post although I've been reading yours for many years.

My question is this: Is it possible that certain exercises or movements can trigger "on time", that is to say when the drug takes effect, and further, is it possible that after retraining the brain to compensate for the loss of ability, one might regain some of that lost ability?

I will try to keep this short and simple. There are two thoughts expressed above.

First, I find that when I am waiting for the Sinemet to take effect, sometimes while sitting down with my legs crossed, that is to say straight out but intertwined so to speak, I can feel and almost force the drug to begin to take effect. I still must wait a significant time (for me normally about 45 min.) but it appears that I am actually triggering the effect. At other times, when I am shaving albeit with great difficulty because I haven't had time to let the pill take effect, I can forcibly kick my toe behind me and into the ground and again, after a sort of toe stomping dance, feel the pill taking effect. At other times, as I sit and wait, the effect simply eases in.

Second, when I was not on any medication nor diagnosed with Parkinson's, I noticed my typing suffered as my right hand digits began to be less responsive to my 70 words per minute typing. This resulted in me hitting the key several times or not at all. This resulted in me gradually using my left hand to type. I confess I got rather good at it but had to force-think as my brain had to retrain to fully use my left hand. Subsequent to this I actually regained the use of my right hand and can now type with both hands as I used to before.

I am a male, 56 years old but diagnosed at the age of 45 after 10 years of doctors unable to decide what I had (symptoms started at the age of 35). Started medication in 2001, Sinemet 25\100, tried several other helper drugs but am largely only using Sinemet, varying between 10\100 and 25\100, trying to understand the difference (there doesn't seem to be much for me).

So, any others with similar situations?
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Old 08-11-2011, 12:55 PM   #2
reverett123
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IGI2-
Yes, something similar happens with me. Somewhere about the 45 to 60 minute mark, it "dawns" on me that it is time to stretch the long muscles and doing triggers the move to full "on".

The best explanation I have for it is tied to insulin, oddly enough. A researcher named Jill Smith found that levodopa/carbidopa blocks insulin's ability to trigger glucose uptake. But she also found that stretching and contracting the muscles restores normal function.


1. J Appl Physiol. 2004 Dec;97(6):2339-46. Epub 2004 Jul 16.

Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase
activity, and insulin-stimulated glucose transport in rat skeletal muscle.

Smith JL, Ju JS, Saha BM, Racette BA, Fisher JS.

Dept. of Biology, St. Louis University, 3507 Laclede Ave., St. Louis, MO 63103,
USA. smithjl@slu.edu

We hypothesized that levodopa with carbidopa, a common therapy for patients with
Parkinson's disease, might contribute to the high prevalence of insulin
resistance reported in patients with Parkinson's disease. We examined the effects
of levodopa-carbidopa on glycogen concentration, glycogen synthase activity, and
insulin-stimulated glucose transport in skeletal muscle, the predominant
insulin-responsive tissue. In isolated muscle, levodopa-carbidopa completely
prevented insulin-stimulated glycogen accumulation and glucose transport. The
levodopa-carbidopa effects were blocked by propranolol, a beta-adrenergic
antagonist. Levodopa-carbidopa also inhibited the insulin-stimulated increase in
glycogen synthase activity, whereas propranolol attenuated this effect.
Insulin-stimulated tyrosine phosphorylation of insulin receptor substrate (IRS)-1
was reduced by levodopa-carbidopa, although Akt phosphorylation was unaffected by
levodopa-carbidopa. A single in vivo dose of levodopa-carbidopa increased
skeletal muscle cAMP concentrations, diminished glycogen synthase activity, and
reduced tyrosine phosphorylation of IRS-1. A separate set of rats was treated
intragastrically twice daily for 4 wk with levodopa-carbidopa. After 4 wk of
treatment, oral glucose tolerance was reduced in rats treated with drugs compared
with control animals. Muscles from drug-treated rats contained at least 15% less
glycogen and approximately 50% lower glycogen synthase activity compared with
muscles from control rats. The data demonstrate beta-adrenergic-dependent
inhibition of insulin action by levodopa-carbidopa and suggest that unrecognized
insulin resistance may exist in chronically treated patients with Parkinson's
disease.


PMID: 15258132 [PubMed - indexed for MEDLINE]



Quote:
Originally Posted by I_Got_it_2 View Post
Hi there. As my login name says, I got it too. Parkinson's, that is. This is my first post although I've been reading yours for many years.

My question is this: Is it possible that certain exercises or movements can trigger "on time", that is to say when the drug takes effect, and further, is it possible that after retraining the brain to compensate for the loss of ability, one might regain some of that lost ability?

I will try to keep this short and simple. There are two thoughts expressed above.

First, I find that when I am waiting for the Sinemet to take effect, sometimes while sitting down with my legs crossed, that is to say straight out but intertwined so to speak, I can feel and almost force the drug to begin to take effect. I still must wait a significant time (for me normally about 45 min.) but it appears that I am actually triggering the effect. At other times, when I am shaving albeit with great difficulty because I haven't had time to let the pill take effect, I can forcibly kick my toe behind me and into the ground and again, after a sort of toe stomping dance, feel the pill taking effect. At other times, as I sit and wait, the effect simply eases in.

Second, when I was not on any medication nor diagnosed with Parkinson's, I noticed my typing suffered as my right hand digits began to be less responsive to my 70 words per minute typing. This resulted in me hitting the key several times or not at all. This resulted in me gradually using my left hand to type. I confess I got rather good at it but had to force-think as my brain had to retrain to fully use my left hand. Subsequent to this I actually regained the use of my right hand and can now type with both hands as I used to before.

I am a male, 56 years old but diagnosed at the age of 45 after 10 years of doctors unable to decide what I had (symptoms started at the age of 35). Started medication in 2001, Sinemet 25\100, tried several other helper drugs but am largely only using Sinemet, varying between 10\100 and 25\100, trying to understand the difference (there doesn't seem to be much for me).

So, any others with similar situations?
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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