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So riddle me this...

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Old 08-11-2011, 01:42 PM   #1
reverett123
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Default So riddle me this...

Epinephrine (aka adrenaline) is made from dopamine.

Because epinephrine is involved in the fight or flight response, it would seem reasonable that if overall dopamine supplies run low, then epinephrine production has priority.

If we have hypervigilant personalities and spend our lives with an increased need for epinephrine, then we are more likely to experience a chronic or recurring shortage of dopamine, the raw material for the epinephrine.

If we have a metabolic problem that limits the amount of dopamine we are capable of turning out, won't our lives and personalities reflect this chronic shortage of this important neurotransmitter, perhaps even generating the "Parkinson's personality"?

Since production of epinephrine/adrenaline worsens the shortage of dopamine, won't we learn early in life to suppress feelings, avoid emotions, etc in order to balance out as best we can?

Finally, while it is by no means certain that the death of neurons in the SN are cause rather than victim, what would be the net result on these neurons if they were forced to strain to function with this constant problem? Would they eventually die?
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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Old 08-11-2011, 03:12 PM   #2
paula_w
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Originally Posted by reverett123 View Post
Epinephrine (aka adrenaline) is made from dopamine.

Because epinephrine is involved in the fight or flight response, it would seem reasonable that if overall dopamine supplies run low, then epinephrine production has priority.

If we have hypervigilant personalities and spend our lives with an increased need for epinephrine, then we are more likely to experience a chronic or recurring shortage of dopamine, the raw material for the epinephrine.

If we have a metabolic problem that limits the amount of dopamine we are capable of turning out, won't our lives and personalities reflect this chronic shortage of this important neurotransmitter, perhaps even generating the "Parkinson's personality"?

Since production of epinephrine/adrenaline worsens the shortage of dopamine, won't we learn early in life to suppress feelings, avoid emotions, etc in order to balance out as best we can?

Finally, while it is by no means certain that the death of neurons in the SN are cause rather than victim, what would be the net result on these neurons if they were forced to strain to function with this constant problem? Would they eventually die?


i agree that everything you said is a strong possibility and it also explains how it could lead to eventual detachment, aloofness, capacity to feel anything. like when i was in a minor car accident, my stomach didn't even feel fear. but i have a ton of anxiety.

i was always considered to be aloof and i didn't hug people till i started meeting pwp. i didn't even like to be touched ...felt that was in my space ..used to think i was '"tactile defensive."

well actually i was

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Old 08-11-2011, 03:21 PM   #3
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Default chicken or the egg

and yes i also believe that emotion suppression and family stress could start with epinephrine suppressing dopamine production.

adding because now i am thinking....as a teacher i could not take my problems to school. i had to be on, pleasant ,even entertaining, patient, etc. then home to two girls and multiple activities. stress, anxiety have been with me forever it seems.
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