The one food that raised my dopamine the most was flax oil. Not because we have great familiarity with eating flax oil refrigderated, but because it contains the type of major fatty acid of green leaves and vegetables, think jungle, alpha linolenic acid, the omega 3 precursor to the ones we most commonly think of, but which may have good effects on its own. I took a tablespoon of it and waited five minutes and got no added dopamine reaction. Then I read this paradox was true for some who are very very deficient in alpha linelenic acit, which I was, but thereafter for 13 straight days I glowed with dopamine for about 3 hours until I finally was no longer deficient in it as signalled by it stopped giving me that extreme dopamine rush, but continued use will cause a constant higher dopamine release on average than if you discontinue, just not tht overwhelming rush.

Steve Lord

Aunt Beanregarding your suggesting I am experiencing food allergies not dopamine suppression, it would submit that it is easy to tell the difference. Each problem has a tell tale feel to it, if one is paying close attention. FOr example a food allergy would be more drastic. Suppression of dopamine is subtle. I paid close attention. I dont think many do. I am interested in such things and believe I am good at perceiving changes in my body. IF I have one skill in life , that is it.

Steve

Im sure no one has experienced this diet because I find that to get the full effect I have to be perfect. IF I eat just one thing that is on the suppression dont eat list, half to all the effect of pleasure throughout the day is lost. Thus if anyone were to test this I would recommend eating only fruits and vegetable , no seasoning, tablespoon of flax oil, no sweet potatoe, no soy read all lables, no olive oil or olives,no nuts dont eat out or someone elses cooking, no other oil except red palm, and flax for say 3 days, 5 days longer than that one would have to add grapeseed for the alpha lenoleic oil requirement but only certain brands are acceptablee like Soeur or salute being rigid like that just to make sure one didnt ruin the test by eating a forbidden food. Actually it might take a week to go to the highest level of dopamine, maybe taking that long to exchange that bad fat in the brain with the good fat.

Steve

Dilmar someone complained that there are too few dopamine cells left such that diet wouldnt matter . I would like to make clear the increase in my dopamine from this diet, throughout the day, even hours after I ate anything, is ENORMOUS judging from how I feel.


STeve

I think one gentleman said dopamine cant get into the brain from the bloodstream but even if it did taking too much omeg 9, in nuts puts a big lid on my dopamine production and pumpkin seeds must have a a fatty acid in them our brains are not familiar enough with andn it balks when I eat those seeds by secreting less dopamine as do most seeds I ever ate, that are in the larger type, A kiwi or blackberry, etc, i.e. smaller seeds , and summer squash seeds are fine however. CHia seeds, sunflower seeds, no good.

I believe that if you can eat this diet perfectly for a few days thereafter you can verify these findings for yourself , because when you make a mistake, eat something that suppresses, its obvious, you will start to feel out of sorts, nerves feel jangled, or tired.

Steve

Once again Billy biff, the increase in my dopamine throughout all waking hours, in me from eating this diet, which Ive been doing religiously for 25 years, is enormous. The degree of improvement that causes in PD can only be speculated , but an enormous increase in dopamine sounds pretty promising to me.

Steve

I am reminded of a david bowie song "station to station"
It's not the side-effects of the cocaine
I'm thinking that it must be love

Reminder--- here is primer on wiki about dopamine and its physiological effects in the body and brain:

https://en.wikipedia.org/wiki/Dopamine

And this is the Kegg pathway of tyrosine metabolism.

Each rectangular box shows a number, and those numbers are enzymes. These enzymes determine when and how much of the other biochemicals are to be made at any one time.

http://www.genome.jp/kegg/pathway/map/map00350.html

Only a tiny amount of dopamine is made in the brain. Dopamine is not a common neurotransmitter there, like histamine, glutamate, and others.
( http://neurotransporter.org/glutamate.html )

http://thebrain.mcgill.ca/flash/d/d_..._03_m_que.html

There is ongoing research today involving the role of glutamate in dopamine disorders (like schizophrenia). This is massively complex and maybe too much so for this forum, but you can Google "Glutamate and dopamine" to find the pathways for this.

The complexity of the chemistry for all the neurotransmitters, is far and above just providing the substrate for their manufacture by the brain. What you eat will be taken by the body as a whole to feed other reactions involving that substrate (which here is tyrosine--see the Kegg pathway link). Any genetic errors in transcripting those enzymes that are responsible for the various reactions, will impact the formation of the desired result.

The genetic research is just beginning. We on the PN forum are seeing that genetic errors, in DNA can lead to nerve damage and pain. The MTHFR mutation is showing up on our PN forum here for all the posters who have the testing done. It is estimated to be a common mutation (10-30%) involving moving methyl groups around in the body, to form the neurotransmitters and do other tissue repair. I believe Muireann, has posted about this here on this forum and if you search her name you will find her posts about it.

So while it is a good thing to consume foods with the tyrosine in them, I do not think that will guarantee you will get a result with that route exclusively to impact Parkinson's disease. There are just too many other factors to consider as well.

think about it, dopamine agonists have a similar structure to dopamine - otherwise they wouldn't bind to dopamine receptors in the brain - and a maximum dosage is 32 MILLIGRAMS per day! that's indicative of how little dopamine is needed in the brain.

a healthy person can eat a 2lb steak with loads of dopamine amino acid precursors and not develop dyskinesias feedback mechanisms in a healthy brain prevents you from producing more dopamine than you need. i'm pretty sure a healthy person taking l-dopa does not get dyskinesias, the systems are still in place to keep dopamine at certain concentrations.

in pd, the cells producing dopamine are damaged or dead, you aren't going to produce any more dopamine by ingesting dopamine precursors, a normal diet has more than enough dopamine precursors in it. what does seem to remain are the enzyme systems which break down dopamine which requires a constant supply of l-dopa.

and, healthy people on a hunger strike or fasting do not develop pd symptoms. think about it.

maybe some non-pd individuals may benefit from a diet but if it had any sig. benefit for pd'ers we'd be using it. everything under the moon was tried prior to l-dopa being approved in the 1970's.

advanced pd'ers have to limit their protein intake.

I guess we'll never know for sure, because no one is interested in trying it.

Steve Lord