Parkinson's Disease Tulip


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Old 10-20-2011, 11:33 AM #1
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Conductor71 Conductor71 is offline
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Conductor71 Conductor71 is offline
Senior Member
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Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Default a pharmacist acknowledges addiction can happen

Hi again,

Sasha, not sure if anyone answered you, but yes I did at one time take meds over night. This was my first inkling of addiction. I think that when your brain wakes you up at the same time every night every two-three hours at wear off times and you cannot get back to sleep without it...that tells you something. My next step was to see doctor about lowering my agonist dosage and that helped me immensely. A sleeping pill that is time release may help but they leave me too brain foggy in AM. Natural things you can try are melatonin or brain entrainment waves (they correspond to our brain states of activity (alpha beta, theta delta) to induce sleep. I plan to try this wave stuf very soon.

Wanted to share this reply by Mark Combes from the the PDF forums . Mark is a pharmacist who also happens to have PD.

This is Mark the pharmacist I run the "ask the Pharmacist" forum. Or is true that even sinemet at high enough doses can cause an addictive/obsessive issues.It is all based on the amount of dopamine in the system.
A good example is this. You have an empty glass, which represents the maximum amount of dopamine you need. The glass is set on a table, the table represents the "feel good" receptors. The water you pour into the glass is dopamine. Once you reach the top, your symptoms are taken care of. Once the water (dopamine) overflows, it hits the "feel good" receptors and cause the feel food seeking behavior. Everyones glass is a different size but, it doesn't matter the source of dopamine that fills the glass. The dopamine agonists have been targeted because they are the quickest at building up (or filling up) the glass. It takes higher doses and a longer time for sinemet, but YES, it can happen.

Hope this clarifies the matter.
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