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10-27-2011, 04:16 PM | #1 | |||
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In Remembrance
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Not to be confused with its less-impressive cousin, the American skullcap. This is a very preliminary report (just two days) but I am very impressed. Two days ago I was relying on a 200/50 Sinemet CR every two hours from 8 AM until 8 PM plus four 10/100s as needed. That's 1800 mg and too much. Today I took the 200/50 CR at 8 AM, 10 AM, Noon, and 2 PM plus two 10/100s. That's 1000 mg. A drop of 800 mg in just two days! Also, I have not had the insomnia that was beginning to be a regular problem at 4 AM nor the cramps in my feet that would follow. As the report pasted below shows, this is a pretty remarkable herb. It is widely available and dirt cheap. More later.
1. CNS Neurol Disord Drug Targets. 2011 Mar;10(2):184-91. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? Gasiorowski K, Lamer-Zarawska E, Leszek J, Parvathaneni K, Yendluri BB, Błach-Olszewska Z, Aliev G. Department of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 14 Kochanowskiego Str., 51-601Wroclaw, Poland. Flavonoids are natural, plant-derived compounds which exert diverse biological activities, also valuable neuroprotective actions within the brain and currently are intensively studied as agents able to modulate neuronal function and to prevent age-related neurodegeneration. Among them, flavones isolated from Scutellaria baicalensis root exhibit strong neuroprotective effects on the brain and are not toxic in the broad range of tested doses. Their neuroprotective potential has been shown in both oxidative stress-induced and amyloid-beta and alpha-synuclein-induced neuronal death models. Baicalein, the main flavone present in Scutellaria baicalensis root, strongly inhibited aggregation of neuronal amyloidogenic proteins in vitro and induces dissolution of amyloid deposits. It exerts strong antioxidative and anti-inflammatory activities and also exhibits anti-convulsive, anxiolytic, and mild sedative actions. Importantly, baicalein, and also another flavone: oroxylin A, markedly enhanced cognitive and mnestic functions in animal models of aging brains and neurodegeneration. In the preliminary study, wogonin, another flavone from Scutellaria baicalensis root, has been shown to stimulate brain tissue regeneration, inducing differentiation of neuronal precursor cells. This concise review provides the main examples of neuroprotective activities of the flavones and reveals their potential in prevention and therapyof neurodegenerative diseases. PMID: 21222632 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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03-10-2012, 08:56 PM | #2 | |||
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Senior Member
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Rick,
In looking at your signature am assuming you are not taking any supplements? Just wondering how this one played out? Thanks! Laura |
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03-11-2012, 09:13 AM | #3 | |||
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In Remembrance
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It has a mild sedating effect for me so I take it at bedtime. As a result I miss out on any symptomatic relief and so have no exciting stories to relate. But given the many good things reported for it and the few bad, I will keep taking it. -Rick
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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"Thanks for this!" says: | Conductor71 (03-11-2012), wordsmithy (03-12-2012) |
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