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11-01-2011, 06:50 AM
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Senior Member
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Why, in spite of Parkinson's, can some movements be repeated easily a large number of times while others are hard to repeat more than a few times?
For instance, I can walk thousands of paces with no change of cadence or stride length, while after only 10 foot taps I progressively slow down and reduce amplitude, such that by 30 I'm almost stuck. John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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11-01-2011, 10:41 AM
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In Remembrance
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Quote:
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paula "Time is not neutral for those who have pd or for those who will get it." |
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11-01-2011, 08:17 PM
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Paula thanks for your reply.
In my case, gross movements are more repeatable than fine movements, leg movements are more repeatable than arm movements. Then some are contextual: the right foot works fine when walking, but not when foot tapping. How do we explain this? Do different movements have different dopamine costs? Is the reservoir of dopamine in some neurons larger than in others, or is the rate of synthesis faster? Do often repeated movements require less dopamine? John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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11-02-2011, 01:20 PM
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In Remembrance
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I wonder if the fact that we have different nervous systems, and the peripheral system is the farthest away. combined with neurotransmitter imbalance -acetylcholine responsible for muscle cramps, norepinephrine for adrenalin, and no inhibition due to gaba shortage .
no links no proof - just speculating. if we lack gaba, we lack inhibition of overfiring?
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paula "Time is not neutral for those who have pd or for those who will get it." |
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Why is it easy to repeat some movements, but not others?
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