[sim00]

A team of researchers at The University of Western Ontario has demonstrated that elimination of one of the neurotransmitters in the part of the brain associated with Parkinson's disease may improve brain function without major adverse effects.

http://www.sciencenewsline.com/medic...900010028.html

http://www.plosbiology.org/article/i...l.pbio.1001194

[paula_w]

Now we are getting somewhere!!!!!!!!!!!!!!!!!!!!!!!

[lindylanka]

Couldn't get through the whole article, but what Paula said!

I have just got back onto an anticholinergic tablet, from using a patch. It has taken a little getting used to, but I am surprised that I am moving so much better. Have discussed this before, so shan't go into it again. I am 11 days in; the patch drug had stopped working, and so had I. Funny thing is my urologist knew it would do this, but my neuros did not!

Paula, you know what you feel, and you have persisted with this. I read the summary thing, whatever he calls it, and it is like the things you have been saying for several years now, especially acetylcholine and glutamate. Win, win for Paula!

[imark3000]

The only PD medicine I took starting one year after diagnosis was an anticholinergic tablet, Camadrin. It worked well by itself for about 2 years controlling my main symptom which is tremor.
I continue to take Kamadrin till the present time together with sinemet.
It is very unpopular with all the neuros that I met particularly for older men because of it's side effects that may include constipation, UTI (Urinary Track Infection) and deterioration of memory and cognition.
I am lucky that it did not cause me any problem that I am aware of.
I have to mention however that I recently caught UTI for the first time in 5 years, that is about 2 weeks ago and was given antibiotic which I took for one week, and now I am on my way to recovery. I believe that it was caused by dehydration due to excessive exercise which I practiced without moderation.
Cheers every body.

Originally Posted by lindylanka

Couldn't get through the whole article, but what Paula said!

I have just got back onto an anticholinergic tablet, from using a patch. It has taken a little getting used to, but I am surprised that I am moving so much better. Have discussed this before, so shan't go into it again. I am 11 days in; the patch drug had stopped working, and so had I. Funny thing is my urologist knew it would do this, but my neuros did not!

Paula, you know what you feel, and you have persisted with this. I read the summary thing, whatever he calls it, and it is like the things you have been saying for several years now, especially acetylcholine and glutamate. Win, win for Paula!

[lindylanka]

I believe (please correct me if I am wrong, someone) that prior to ldopa anticholinergics were used for control of symptoms.

[imark3000]

Originally Posted by lindylanka

I believe (please correct me if I am wrong, someone) that prior to ldopa anticholinergics were used for control of symptoms.

Interestingly, Kamadrin (Procyclidne HCL) was never recommended to me by Neuros specializing in PD but only agreed reluctantly to use it. Kamadrin was in fact recommended for me by a psychiatrist friend of mine who got his medical qualification in UK in the seventies and I speculate that he was not exposed to the standard medical drill against Anticholinergic drugs as Sinemet and L-dopa were relatively new.
I have to stress that in no way, I am recommending Anticholinergic drugs as I do believe that they carry their own serious side effects.
Cheers every one and hearty wishes to conquer PD.
Imad

[lindylanka]

You are right about at least some of them, muzzy brain/thinking is one of them, so not indicated for AD & PD , though I think they are affected differently. Also there are a lot of them, targeted at different conditions.