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11-23-2011, 12:15 PM
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Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?
Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID: 17184173 Rajeswara Babu Mythri, Balusamy Jagatha, Nityananda Pradhan, et al Article Affiliation: Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. Abstract: Selective damage of mitochondrial complex I within the dopaminergic neurons of the substantia nigra is the central event during Parkinson disease. Peroxynitrite is one of the important free radicals probably mediating complex I damage. Peroxynitrite inhibits brain complex I mainly by 3-nitrotyrosine and nitrosothiol formation, but how these modifications alter the structure-function relation of complex I is unclear. Curcumin pretreatment protects brain mitochondria... in vivo by elevation of total cellular glutathione levels... Pubmed Data : Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID: 17184173 Article Published Date : Mar 01, 2007 http://www.greenmedinfo.com/article/...ave-value-prev
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