Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 11-29-2011, 03:13 PM #1
GerryW's Avatar
GerryW GerryW is offline
Member
 
Join Date: Nov 2011
Location: Marysville, WA
Posts: 613
10 yr Member
GerryW GerryW is offline
Member
GerryW's Avatar
 
Join Date: Nov 2011
Location: Marysville, WA
Posts: 613
10 yr Member
Default Gluten and PD

My TCM doctor told me that her daughter developed gluten sensitivity that didn't manifest as the usual enteric symptoms but as neurological ones. This is not uncommon. Though only 21 she moved like an 80 year old with shuffling gait as well as slurred speech and fatigue. These symptoms disappeared when she went on a gluten-free diet. That made me curious so I googled gluten and PD. There were a lot of links but two I found interesting. One said that Michael J. Fox's symptoms abated while visiting Bhutan where gluten is not found in the food (also verifying that dopaminergic cells are dormant, not dead). The other talked about gluten and GABA.

Here is an excerpt from that article:

"A key enzyme of the subthalamic nucleus (STN) is glutamic acid decarboxylase (GAD) that was mentioned earlier. GAD helps convert glutamic acid or glutamate into GABA. Glutamate is a most powerful neural stimulator and GABA is a most powerful neural inhibitor. In Parkinson’s Disease as well some other disorders, GAD levels drop causing an imbalance in the regulation of the conversion of glutamate to GABA disrupting the entire cascade.

I bring this up in the context of gluten sensitivity because according to the research of Dr. Marios Hadjivassiliou in the UK one common antibody created in the gluten sensitivity complex of antibodies is to the enzyme GAD. People who are gluten sensitive tend to increase production of the antibody to GAD. This is important not just in the basal ganglia but also other parts of the brain that are important for focus, learning and general movement control. Problems with gluten sensitivity leading to decreased GAD have been linked to ADD and ADHD, dementia, headaches, insomnia, cerebellar ataxia, Parkinsonian syndromes and others."

Gene therapy is aimed at restoring GAD, the better to produce more GABA. Acetylcholine tightens muscles and dopamine relaxes muscles. Normally, they are in balance but when dopamine gets depleted acetylcholine predominates leading to tremors and rigidity. Gamma-aminobutyric acid (GABA), is a chemical that reduces how sensitive muscle cells are to stimulation from the brain. It is also depleted in the brains of those with PD. Experiments using gene therapy to increase the brain's supply of GABA have been successful at controlling symptoms. Normally, synthetic GABA does not get into the brain if taken orally but a natural form (PharmaGABA) does and might be worth trying.
It might also be useful to go gluten-free for a while to see if it helps.
GerryW is offline   Reply With QuoteReply With Quote

advertisement
Old 11-29-2011, 05:03 PM #2
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
15 yr Member
paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
15 yr Member
Default good points

Quote:
Originally Posted by GerryW View Post
My TCM doctor told me that her daughter developed gluten sensitivity that didn't manifest as the usual enteric symptoms but as neurological ones. This is not uncommon. Though only 21 she moved like an 80 year old with shuffling gait as well as slurred speech and fatigue. These symptoms disappeared when she went on a gluten-free diet. That made me curious so I googled gluten and PD. There were a lot of links but two I found interesting. One said that Michael J. Fox's symptoms abated while visiting Bhutan where gluten is not found in the food (also verifying that dopaminergic cells are dormant, not dead). The other talked about gluten and GABA.

Here is an excerpt from that article:

"A key enzyme of the subthalamic nucleus (STN) is glutamic acid decarboxylase (GAD) that was mentioned earlier. GAD helps convert glutamic acid or glutamate into GABA. Glutamate is a most powerful neural stimulator and GABA is a most powerful neural inhibitor. In Parkinson’s Disease as well some other disorders, GAD levels drop causing an imbalance in the regulation of the conversion of glutamate to GABA disrupting the entire cascade.

I bring this up in the context of gluten sensitivity because according to the research of Dr. Marios Hadjivassiliou in the UK one common antibody created in the gluten sensitivity complex of antibodies is to the enzyme GAD. People who are gluten sensitive tend to increase production of the antibody to GAD. This is important not just in the basal ganglia but also other parts of the brain that are important for focus, learning and general movement control. Problems with gluten sensitivity leading to decreased GAD have been linked to ADD and ADHD, dementia, headaches, insomnia, cerebellar ataxia, Parkinsonian syndromes and others."

Gene therapy is aimed at restoring GAD, the better to produce more GABA. Acetylcholine tightens muscles and dopamine relaxes muscles. Normally, they are in balance but when dopamine gets depleted acetylcholine predominates leading to tremors and rigidity. Gamma-aminobutyric acid (GABA), is a chemical that reduces how sensitive muscle cells are to stimulation from the brain. It is also depleted in the brains of those with PD. Experiments using gene therapy to increase the brain's supply of GABA have been successful at controlling symptoms. Normally, synthetic GABA does not get into the brain if taken orally but a natural form (PharmaGABA) does and might be worth trying.
It might also be useful to go gluten-free for a while to see if it helps.
the transmiitters are out of balance. norepinephrine has also been missing at autopsy; so we have two toxic agressors - glutamate and acetylcholine- toxic and damaging - dopamine has both excitatory and inhibitory aspects; gaba [the main brake] is reduced. norepinephrine is a pre adrenalin fight or flight - reduced.
it is imho too much excitatory and not enough inhibition. its a huge overfiring , damaging as i t goes along causing muscle cramping, dystonia, anxiety,protein misfolding, depletes dopamine and other transmitters and causes chaotic and painful bone, muscle and joint problems among many other things . it's a meltdown and i agree with your transmitters being involved - all of them.
__________________
paula

"Time is not neutral for those who have pd or for those who will get it."
paula_w is offline   Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
is it all about gluten? Merrilee New Member Introductions 11 03-22-2010 06:01 PM
Gluten?? rscowboy2005 Peripheral Neuropathy 3 12-05-2009 07:08 PM
Gluten & PD Ronhutton Parkinson's Disease 11 04-10-2009 02:25 AM
THE GLUTEN FILE .to ubderstand gluten prosses jenD Epilepsy 3 06-11-2007 06:51 AM
Dr Gluten comes to the US annelb Gluten Sensitivity / Celiac Disease 2 09-29-2006 01:37 PM


All times are GMT -5. The time now is 08:59 AM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.