Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 12-06-2011, 05:30 PM #1
sim00's Avatar
sim00 sim00 is offline
Member
 
Join Date: Jun 2011
Location: Italy
Posts: 192
10 yr Member
sim00 sim00 is offline
Member
sim00's Avatar
 
Join Date: Jun 2011
Location: Italy
Posts: 192
10 yr Member
Default Another piece in the puzzle...

http://www.pnas.org/content/early/20...56108.abstract

http://www.uniroma1.it/sites/default...olo%20Pnas.pdf

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.

Abstract

DOPA decarboxylase, the dimeric enzyme responsible for the synthesis of neurotransmitters dopamine and serotonin, is involved in severe neurological diseases such as Parkinson disease, schizophrenia, and depression. Binding of the pyridoxal-5′-phosphate (PLP) cofactor to the apoenzyme is thought to represent a central mechanism for the regulation of its activity. We solved the structure of the human apoenzyme and found it exists in an unexpected open conformation: compared to the pig kidney holoenzyme, the dimer subunits move 20 Å apart and the two active sites become solvent exposed. Moreover, by tuning the PLP concentration in the crystals, we obtained two more structures with different conformations of the active site. Analysis of three-dimensional data coupled to a kinetic study allows to identify the structural determinants of the open/close conformational change occurring upon PLP binding and thereby propose a model for the preferential degradation of the apoenzymes of Group II decarboxylases.
__________________
Sim00

Born in 1969, diagnosed PD in 2007, first symptoms 2004. DBS in July 2016.
sim00 is offline   Reply With QuoteReply With Quote

advertisement
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
A piece of the puzzle in the causation story Muireann Parkinson's Disease 5 09-13-2011 11:48 AM
Piece By Piece BobbyB ALS News & Research 0 03-03-2009 03:10 PM


All times are GMT -5. The time now is 06:34 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.