Parkinson's Disease Tulip


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Old 12-10-2011, 03:05 AM #1
boytos boytos is offline
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boytos boytos is offline
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Default Why EPO is not used for PD ?

Given this :

http://search.engrant.com/project/AV...nson_s_disease
http://www.ncbi.nlm.nih.gov/pubmed/19101524

It seem to create new dopaminergic neurons.

Furthermore, EPO is remarkably effective in protecting
and developing dopaminergic neurons and in protecting dopaminergic neuron loss
in a mouse model of Parkinson's disease
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Old 12-10-2011, 08:13 AM #2
soccertese soccertese is offline
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soccertese soccertese is offline
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email the lead researcher and ask him/her why not. maybe a subsequent experiment didn't work. you'd think whomever mfg's epo would be very interested but since epo sure doesn't enhance red blood cell production unless administered frequently, is very expensive, has side affects and could possibly cause brain damage in too high a dose .....

question is, does epo get to the human brain, does it pass the bbb?
should be easy to create human neurons from stem cells and test in vitro if neuroprotective. but i'm sure if you google mice/neuroprotective you'll find hundreds of compounds that are experimentally neuroprotective.

Last edited by soccertese; 12-10-2011 at 11:18 AM.
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Old 12-10-2011, 09:19 AM #3
boytos boytos is offline
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that sure, it induce the differentiation of stem cells with very little dose, if there is a way to increase or give stem cell..

For bbb :

http://www.news-medical.net/news/201...human-EPO.aspx

Last edited by boytos; 12-10-2011 at 12:36 PM.
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