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12-22-2011, 11:51 PM
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Massachusetts General Hospital investigators appear to have found the mechanism behind a previously reported link between the rare genetic condition Gaucher disease and the common neurodegenerative disorder Parkinson's disease. In a report to appear... they describe how disruption of the molecular pathway that causes Gaucher disease leads to the toxic neuronal deposits of the protein alpha-synuclein (α-syn) found in Parkinson's and related disorders. In addition, rising α-syn levels further inhibit the Gaucher's-associated pathway, leading to even more α-syn deposition, a finding that indicates therapies targeting this pathway may be a new option for patients with Parkinson's disease...
http://medicalxpress.com/news/2011-0...e-insight.html
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| "Thanks for this!" says: | sim00 (12-23-2011) |
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