I tried liquid, sub lingual tabs, etc. I absolutely did not get the benefit from other forms at the level I get from the injected form. I use a very tiny insulin syringe into the upper buttock. It's a very easy and quite painless injection. Occasionally, I add 25 IU B6. I really feel that injecting is a far more reliable method as it is not at the mercy of the contents of one's stomach.
I believe that the dose translates into .5 grams. I mail order the B12, no prescription needed.

Could you clarify this please? For safety concerns:

.5grams of what? Neither item you posted should be used in this high a dose.

Injected B12 comes in the 1000mcg/ or 1milligram per cc in the injectable form. (.5gram= 500 milligrams).

B6 does not come in IUs either. It is listed as mg/ml if injected.
Don't go high on B6... in high doses, it can affect the nerves causing a form of neuropathy.

navigating 23 and me website
 

For those individuals who have had DNA profiling, check for polymorphisms of the methylenetetrahydrofolate reductase (MTHFR C677T), methyltetrahydrofolate-homocysteine methyltransferase (MTR A2756G), and 5-methyltetrahydrofolate-homocysteine methyltransferase reductase both associated with folate metabolism and in addition, check (MTRR A1049G and C1783T) associated with processing of B12 in the bodY. If you have mutations in the MTHFR gene, must use a breakdown product of folic acid, methyl folate, and folinic acid if one has the other mutation. Mutations in MTRR requires a B 12 supplement.[/QUOTE]

@olsen - hi-
can i access this on 23andme website, and if so where could i find this info? thanks for posting!
sharilyn

Folic acid variants, B12 variants and homocysteine levels
 

Hi Moondaughter, hope this helps:
click on your "browse raw data" listed under the "account" heading next to your name at the right hand top of the page on your Home page on 23andme

The SNPs to put into the corresponding SNP area are: rs 1801133 and rs1801131. These are the MTHFR genes.One finds them listed as C677T (1081133)or A1298C(1801131) polymorphisms of the MTHFR gene, Methylfolate reductase.

Next input rs602662. This corresponds to B12 metabolism.



For MTHFR gene:
rs1801133 A is the risk allele
rs1801131, risk allele G
SNPedia:
Homozygous rs1801133(T;T) individuals have ~30% of the expected MTHFR enzyme activity, and rs1801133(C;T) heterozygotes have ~65% activity, compared to the most common genotype, rs1801133(C;C). This reduced activity (i.e. this SNP) has been linked at least once to each of the following disorders (though not necessarily reproducibly):

The lack of MTHR enzyme activity leads to higher homocysteine levels ( good explanation of high homocysteine and problems caused by: http://drbenkim.com/articles-homocysteine.html)

former posting about this issue:

http://neurotalk.psychcentral.com/sh...ighlight=MTHFR

There are a few supplements which have the breakdown product l-methylfolate of folic acid which one can purchase over the internet. You may also obtain l-methylfolate by prescription from your doctor: l-methylfolate : Metanx, Cerefolin, Deplin. These can bypass the defective enzyme if you have the risk variant for rs1801133. If you have the rs1081131 variant, you will also need to obtain a supplement which contains the available source of folic acid, 5-formyl tetrahydrofolate. The only brand I know for this is: ActiFolate. It is made by Metagenics and is a blend of L-5 methyl tetrahydrofolate (L-5-MTHF), 5-formyl tetrahydrofolate (5-formyl THF), and folic acid. "This all-inclusive, bioavailable source of folate nutrition is perfect for patients who require general folate supplementation.*(I think MrsD also listed a few other sources; you could search thru the postings about folic acid for any of MrsD's posts)

(following from the web site for the supplement:)
Encourages methylation pathways at various points of folate metabolism, which may better support overall methylation than a single form of folate—especially in those with genetic variations in folate metabolism.*
Features L-5-MTHF, a body-ready, nature identical folate that will not mask B12 deficiency and is the only folate that crosses the blood-brain barrier.*
Encourages overall good health by promoting cardiovascular health, mental function, detoxification, maintenance of DNA, prenatal health, and breast health.*
Delivers the biologically active folates that are most commonly found in vegetables.*
Critical for people whose folate status may be affected by genetic variation.*

For the B12 gene:
https://www.23andme.com/you/journal/...irus/overview/
B12 gene:
rs602662
GG= lowest B12 blood levels
AG= low B12 blood levels
AA= normal

(please ignore the emoticon; my touch is too hard, I think, or as one poster queried, perhaps my fingers are too fat?)

Hint:

The emoticon shows up because there is no space after the last word.

Colon + ) = :)

So after writing some text that ends in punctuation, put a space before any ; or : or ) etc. And then the emoticon won't show up.

I've learned this the hard way myself! ;)

Also be careful of [ and ] and any punctuation in a link.

Thanks!
 

Thankyou ever so much for this! I am humbled by your most comprehensive response - looks like my rs602662 is in the GG category-i've just started to analyze my profile and you have given me much needed instruction, thankyou! sharilyn

Lindy,

Could you elaborate on this? I had PD pre-pregnancy but my condition worsened due to something pregnancy related. What is your link between pregnancy, PD, and B12?

Also, has anyone tried the spray version of B12? I confess that I don't take as many supplements I may need because I loathe taking pills all the time.


Laura

Hi,
The first thing I was ever told not to take (by a movement disorders professor) when P.D. was diagnosed was B6 (pyridoxine) in supplement form.
I took his word for it!
It interferes with absorption of levodopa.

Laura,

Did you receive 'gas and air' anaesthesia in childbirth, brand name Entonox? This can induce b12 deficiency and consequent neurologic probs.

See http://www.ncbi.nlm.nih.gov/pubmed/17404524

No, I did not unless it can be done with a spinal block? I delivered by c-section here and was conscious but could not feel anything from waist down.

Thanks though! Is what you suggested common in UK?

Laura