Methylcobalamin: A Potential Breakthrough in Neurological Disease

mrsD · 02-10-2012, 01:53 PM

Nitrous oxide used to be used in labor and delivery.

It is also used in dental offices. And now is common in raves attended by young people. They fill balloons with it, and sell them to inhale from.
http://www.ncbi.nlm.nih.gov/pubmed/21739392

http://www.ncbi.nlm.nih.gov/pubmed/19169627

occupational hazard:
http://www.ncbi.nlm.nih.gov/pubmed/18763150

http://www.ncbi.nlm.nih.gov/pubmed/17951609

If a person is marginal in B12 level, one exposure may precipitate low B12 symptoms. Otherwise it is more chronic exposures that are harmful in people with normally higher levels.

Muireann · 02-10-2012, 01:55 PM

It is extremely common in Ireland. I don't know about UK practices. Quite a few forms of anaesthesia contain substances that deplete b12. Plus if you are under a lot of stress you will burn up your reserves of b12.

moondaughter · 02-10-2012, 03:44 PM

Quote:

Originally Posted by Muireann

It is extremely common in Ireland. I don't know about UK practices. Quite a few forms of anaesthesia contain substances that deplete b12. Plus if you are under a lot of stress you will burn up your reserves of b12.

I was born in 1957 - my mother took diethyl ether (something like that) at my birthing - also diethylstiburol at 6 months gestation.
if one does not present with symptoms of depression would a folate substance still be indicated to take in combination with b12?

I think the sublingual b12 is already having an effect on me - i feel a bit stronger later in the day and more on time with sinemet. a big thanks to all who contribute to this thread

sharilyn

mrsD · 02-10-2012, 04:06 PM

Many of our foods are enriched with folate.

It is not necessary to take folate with B12, unless you are anemic, or have blood work showing it is low. But in the US today, low folate is less common because of food enrichment.

However, taking folate without knowing if B12 is low, can be
serious. This masks the need for B12 and can result in nerve damage over time. This is one reason why folic acid at 1mg or above requires an RX in the US.

Conductor71 · 02-10-2012, 04:43 PM

Quote:

Originally Posted by mrsD

Many of our foods are enriched with folate.

It is not necessary to take folate with B12, unless you are anemic, or have blood work showing it is low. But in the US today, low folate is less common because of food enrichment.

However, taking folate without knowing if B12 is low, can be
serious. This masks the need for B12 and can result in nerve damage over time. This is one reason why folic acid at 1mg or above requires an RX in the US.

Has anyone tried or know relative efficacy of using vitamin b12 in an oral spray form vs. sublingual or capsule?

Thanks!

mrsD · 02-10-2012, 04:49 PM

There are many studies now that oral works.

IMO you need to take on an empty stomach for best results,
however.

The other venues cost alot of money!

reverett123 · 05-03-2013, 02:43 AM

and an apology to the "ladies" (you are "ladies", aren't you?) for missing it the first time through. Something about childbirth makes men disappear into the undergrowth, but we are happy to assist at the conception.

mrsD · 05-03-2013, 04:50 AM

There is a new video on YouTube about B12:

http://www.youtube.com/watch?v=BvEiz...ature=youtu.be

It is very sobering. However, it only mentions methylB12 near the end.

BTW methylcobalamin is now available at Costco in a 250 count bottle for $19.99. That's about 6 cents a pill.
Also Walgreen's is now carrying it in stores, by Nature's Bounty.

I see this as progress in addressing the common problem of low B12 in the US!

VICTORIALOU · 05-09-2013, 07:46 AM

Thank you so much for sharing this.
I can think of so many people I want to share this information with.

[QUOTE=mrsD;980278]There is a new video on YouTube about B12:

http://www.youtube.com/watch?v=BvEiz...ature=youtu.be

It is very sobering. However, it only mentions methylB12 near the end.

BTW methylcobalamin is now available at Costco in a 250 count bottle for $19.99. That's about 6 cents a pill.
Also Walgreen's is now carrying it in stores, by Nature's Bounty.

I see this as progress in addressing the common problem of low B12 in the US![/QUOTE]

lindylanka · 05-09-2013, 05:33 PM

Sorry Laura, i did not realise you had posted a question to me. I am not basing my conjecture on the mention of B12 post-pregnancy, though there are many mentions on sites dealing with B12 deficiency that pregnancy can be a drain on reserves, especially in the case of vegetarian and vegan people. Rather I was referring to people over the years who mentioned that they developed PD within a few years of having a child. I am one of those, my son was under 4 when I got the first symptoms. If anyone has done any work on this specifically, I would be really interested to read it. :-)

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