If you already have noted this one, my apologies:


1. Mol Nutr Food Res. 2006 Feb;50(2):229-34.

Green tea catechins as brain-permeable, natural iron chelators-antioxidants for
the treatment of neurodegenerative disorders.

Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MB.

Eve Topf, Haifa, Israel. mandel@tx.technion.ac.il

Neurodegeneration in Parkinson's, Alzheimer's, or other neurodegenerative
diseases appears to be multifactorial, where a complex set of toxic reactions,
including oxidative stress (OS), inflammation, reduced expression of trophic
factors, and accumulation of protein aggregates, lead to the demise of neurons.
One of the prominent pathological features is the abnormal accumulation of iron
on top of the dying neurons and in the surrounding microglia. The capacity of
free iron to enhance and promote the generation of toxic reactive oxygen radicals
has been discussed numerous times. The observations that iron induces aggregation
of inert alpha-synuclein and beta-amyloid peptides to toxic aggregates have
reinforced the critical role of iron in OS-induced pathogenesis of
neurodegeneration, supporting the notion that a combination of iron chelation and
antioxidant therapy may be one significant approach for neuroprotection. Tea
flavonoids (catechins) have been reported to possess divalent metal chelating,
antioxidant, and anti-inflammatory activities, to penetrate the brain barrier and
to protect neuronal death in a wide array of cellular and animal models of
neurological diseases. This review aims to shed light on the multipharmacological
neuroprotective activities of green tea catechins with special emphasis on their
brain-permeable, nontoxic, transitional metal (iron and
copper)-chelatable/radical scavenger properties.

PMID: 16470637 [PubMed - indexed for MEDLINE]

Very interesting article, reverett. Thanks for that.

I also found this article about chelation in AD:
http://www.dementiatoday.net/article...sease-process/

It starts to make more and more sense. The misfolded protein is the result of iron accumulation. It would be interesting to see the combined effect of removing iron, adding magnesium, adding vitamines, insert neurotrophic factors and anti-oxidants. This might one day be a valid therapy. But what is the main cause of all these combined problems ?

I take a liquid Calcium, Magnesium , zinc and d3 supplement from Earth Fare (their label)
I know the product is absorbable because my friends front teeth gradually became whiter.
That told me alot and I started on it about a year ago..1 TBS a day.

Speaking of supplements, is anyone familiar w Dr. Marty Hinz and his amino acid therapy? Also,please what is the difference between N A C and L Cysteine? What amino acids, if any, do you take on a regular basis?

the board's search function should bring up earlier discussion on amino acid therapy and HINZ

There was a thread about Dr. Marty Hinz and his amino acid therapy posted not long ago -

http://neurotalk.psychcentral.com/sh...ghlight=gerryw

Yes, indeed, thanks! And I see I even posted on this very thread. I saw the amino acid therapy idea on another website and didn't immediately relate it to what has already been hashed thru here. Thing is I was doing better with creatin and l carnitine, then read the Hinz stuff, went to whole foods and bought the other amino acids Hinz mentions and, took those two days ago and unfortunately, my improvement stopped and my tremors got worse. Hopefully, this is temporary in nature, but that is why I ask about others experiences with amino acids. In the meantime, I'm going back to creatine and l carnitine and keep it simple for now.