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02-11-2012, 01:43 PM | #1 | ||
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Novel Magnesium Compound Reverses Neurodegeneration
Scientists have been challenged to find a way to raise magnesium levels in the brain.8 Even intravenous infusions cause only a modest elevation of magnesium levels in the central nervous system.22 An innovative team of researchers from the Massachusetts Institute of Technology (MIT) recently found a way to surmount this obstacle. They formulated a new magnesium compound called magnesium-L-threonate or MgT that in lab tests allows for oral administration while maximizing magnesium "loading" into the brain.7,8 Based on prior research, they meticulously documented that increased levels of magnesium in the brain promote synaptic density and plasticity in the hippocampus.14 Up until now, however, no widely available forms of magnesium met the criteria needed for rapid absorption and efficient transfer into the central nervous system.8 By contrast, MgT yielded compelling results. MgT oral supplements increased magnesium levels in spinal fluid, an index of measurement in brain magnesium by about 15%, while none of the other magnesium compounds tested produced significant elevations.8 While a 15% increase may not sound like a lot, it induced a profound effect on neurological function. To evaluate the effects of MgT on memory, the researchers tested it against currently available magnesium compounds. They used a simple assessment of learning and memory called the Novel Object Recognition Test or NORT. A high NORT score means that the animal is good at recognizing and identifying new objects, a skill that is critical in aging humans as well.8 NORT is a good test of function in the hippocampus, which is rich in the NMDA receptors so closely controlled by magnesium.23 The researchers put aged animals through the NORT test, supplementing them with MgT or one of the commercially available magnesium compounds. Only MgT significantly enhanced both short- and long-term memory, boosting scores by 15% for short-term memory and 54% for long-term memory compared to magnesium citrate.8
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Imad Born in 1943. Diagnosed with PD in 2006. |
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"Thanks for this!" says: |
02-11-2012, 02:50 PM | #2 | ||
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Thanks for sharing. |
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"Thanks for this!" says: |
02-11-2012, 09:34 PM | #3 | ||
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cheers Imad
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Imad Born in 1943. Diagnosed with PD in 2006. |
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"Thanks for this!" says: | VICTORIALOU (09-17-2012) |
09-17-2012, 09:57 AM | #4 | ||
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http://www.jbc.org/content/277/18/16116.full
I found this also a very interesting article explaining the importance of iron and magnesium in PD pathology. |
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"Thanks for this!" says: | VICTORIALOU (09-17-2012) |
09-17-2012, 10:47 AM | #5 | ||
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Magnate
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keep in mind this MIT article was back in 2010 and LIFE EXTENSION is in the business of selling supplements.
and this was tested only in rats. here's the article the LEF article cites, not much there. http://www.mit.edu/press/2010/magnesium-supplement.html For Immediate Release: January 27, 2010 contact: Jen Hirsch, MIT News Office email: newsoffice@mit.edu phone: 617-253-2700 share Magnesium supplement helps boost brainpower CAMBRIDGE, Mass. — Neuroscientists at MIT and Tsinghua University in Beijing show that increasing brain magnesium with a new compound enhanced learning abilities, working memory, and short- and long-term memory in rats. The dietary supplement also boosted older rats’ ability to perform a variety of learning tests. |
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"Thanks for this!" says: | VICTORIALOU (09-17-2012) |
09-17-2012, 12:43 PM | #6 | |||
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Magnesium supplement helps boost brainpower
CAMBRIDGE, Mass. — Neuroscientists at MIT and Tsinghua University in Beijing show that increasing brain magnesium with a new compound enhanced learning abilities, working memory, and short- and long-term memory in rats. The dietary supplement also boosted older rats’ ability to perform a variety of learning tests.[/QUOTE] I've been taking this supplement - I'm not hearing loud churchbells from it but i do feel compelled to take it-its so hard to know if this supplement is the reason i do feel on occassion improvement to my memory and communication but intuitively it seems very good.
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Smooth seas do not make skillful sailors.... Nature loves courage. “The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” ~ Nikola Tesla |
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09-17-2012, 12:50 PM | #7 | ||
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I remember vaguely an article about an agent that removed iron from the brain. If only I could remember a bit more about that article. I think it would be worth to test this agent in combination with magnesium in some clinical trial. |
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09-17-2012, 01:37 PM | #8 | ||
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Magnate
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09-17-2012, 03:41 PM | #9 | ||
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09-17-2012, 03:59 PM | #10 | ||
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Hmmm, I found more interesting results about chelation:
http://www.scopus.com/record/display...LTtfBmnudv%3a2 http://www.hindawi.com/journals/ijcb/2012/983245/#B75 I can't wait for the clinical phase II results of the chelation trial. |
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