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01-09-2012, 11:32 AM | #1 | ||
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Magnate
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01-09-2012, 12:46 PM | #2 | ||
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Senior Member
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From the paper referenced:
"[Possibly] the effects of neurodegeneration can be counteracted to some extent by introducing more noise in the CNS." [1] "Noisy sensory signals can be transmitted to the CNS through any sensory pathway, ..." [1] Has anyone tried a noisy (irregular pulses) TENS machine? [1] "Noisy Galvanic Vestibular Stimulation Promotes GABA Release in the Substantia Nigra and Improves Locomotion in Hemiparkinsonian Rats" Ghazaleh Samoudi, Hans Nissbrandt, Mayank B. Dutia and Filip Bergquist http://www2.sahlgrenska.gu.se/pressimages/brus.pdf John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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01-09-2012, 01:40 PM | #3 | ||
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Magnate
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Quote:
neurologix is/was implanting a gaba gene in the brain in phase1/phase2 but a different area |
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01-09-2012, 02:13 PM | #4 | |||
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In Remembrance
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There have been a number of reports of PWP exhibiting synchronous firing of blocks of neurons. Too much order. You have to have a little chaos in the system. Kind of the way a radio transmits using a highly ordered carrier wave as a baseline with a data laden broadcast wave paired with it.
We talk about music helping us function by providing a rhythmic beat that we can move to. Maybe we have it backwards and the music actually helps by partially overcoming the excessive order that is so characteristic of PD?
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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"Thanks for this!" says: | anon72219 (01-10-2012), moondaughter (01-10-2012) |
02-21-2012, 07:37 PM | #5 | ||
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Senior Member
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More on the same theme.
Although still in its early days, with testing being done on rats, a paper by Bergquist [1] is very interesting. The diagrams are superb. "Low extracellular dopamine levels produce insufficent neural noise – this impairs signal transmission/system function. Adding moderate noise to a low noise system will improve neural functions, if it is not optimal to begin with." "Stochastic vestibular stimulation • Non invasive. • Low amplitude (<1 mA) currents selectively activates vestibular afferents. • By using a noisy stimulation pattern, the vestibular system is activated without inducing the sensation of movement (vertigo)." [1] "The effect of sensory noise on basal ganglia function in hypodopaminergic conditions" Filip Bergquist, MD, PhD Dept of Neurology, Sahlgrenska University Hospital, Gothenburg Sweden Dept of Pharmacology, University of Gothenburg, www.dsls.usra.edu/20111118.pdf John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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02-22-2012, 12:47 PM | #6 | ||
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