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05-11-2012, 10:05 AM
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Has there been other info about this?
It sounds very promising.  http://www.yissum.co.il/technologies/project/7-2006-138 7-2006-138 | L-DOPA Amide Derivatives for Treating Parkinson’s Disease Atlas Daphne, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences Novel treatment for Parkinson’s disease overcomes “on-off” phenomenon Development Stage Concept proven, in vivo human models Patent Status Pending patent application in, Europe, US and Israel (PCT publication № WO2004/069146) Highlights Increases the endogenous level of dopamine to alleviate the motor complications of Parkinson’s disease and to delay the onset of the symptoms from the dramatic decrease in dopamine Formulated for buccal, oral, sub-lingual, parenteral, intranasal, intramuscular, intravenous, subcutaneous, intraduodenal or rectal administration Our Innovation Provides a pharmaceutical preparation for the treatment of patients suffering from PD comprising a composition of L-Dopamide A water-soluble compound could be applied f for rescue therapy. An advantage over the insoluble L-DOPA Involves an essential structural change to make L-DOPA more soluble and resistant to DOPA Decarboxylase Administrable without Carbidopa due to resistance to DOPA-decarboxylase L-Dopamide is slowly hydrolyzed to L-DOPA because it is resistance to DOPA decarboxylase Slow release addresses the on/off phenomenon of Parkinson’s Degrades to natural products The Opportunity Addresses the need for more effective therapy for Parkinson’s disease using a more sustained level of dopamine Oral results Oral application in animal model showed longer duration > 40% over L- DOPA. Higher efficiency as a proof of concept in experiments made side by side with L-DOPA PK studies available Development Milestones Ready for toxicology studies. Patent Status Granted US 8,048,926
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VictoriaLou . |
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L-DOPA Amide pending patent
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