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05-28-2012, 02:11 PM | #1 | ||
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Hi everyone,
I was reading about the clinical trials on Inosine and Isadiprine. Anyone has some more information about the current state of these trials ? It's not easy to find this information. In 2008 there was a phase 2 clinical trial for Inosine. I guess this trial should be done already. |
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06-02-2012, 11:37 AM | #2 | ||
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Member
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MJFF supported both of these trials.
The Isradipine study, also called STEADY-PD is complete. The lead investigator has recently finished analyzing the data and will be presenting the study results in three weeks at a scientific conference, the annual meeting of the Movement Disorders Society. So results will be public soon. Information on the study from the MJFF grant database is here: http://www.michaeljfox.org/research_...s_3.cfm?ID=486 The Inosine study, aka SURE PD, is still ongoing; they have finished recruiting for the study, but are still following and evaluating enrolled subjects, and results from this study are expected late summer/early fall 2013. A press release from the inosine study is here: http://www.michaeljfox.org/newsEvent...cle.cfm?ID=244 A bit more from our grant database is here:http://www.michaeljfox.org/research_...s_3.cfm?ID=403 Debi |
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06-02-2012, 01:37 PM | #3 | ||
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Debi,
Many thanks for this info. |
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06-26-2012, 10:17 AM | #4 | ||
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Guest
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https://www.michaeljfox.org/foundati...bon-Highlights
I guess the phase II trial didn't prove anything. |
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06-26-2012, 03:45 PM | #5 | ||
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Senior Member
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We actually were taking isradipine for quite awhile (from a willing doc who scripted it for us) but were not able to discern any benefit whatsoever, nor did our neuro. It's a calcium channel blocker, if I remember correctly, and while it may do that, I think there is so much else going on that simply trying to keep excess calcium from building up in the cell just isn't enough to really make a difference. This is our personal experience, though, and subjective observations, trial of one, and mere lay opinion.
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06-26-2012, 04:49 PM | #6 | |||
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Member
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I took isradipine for a while and the only difference was that it made me urinate a lot, in fact, too much so I had to quit. It is, if I am not mistaken, the only calcium channel blocker that has diuretic properties.
Still, if it cured the disease I'd get a leg bag! |
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06-26-2012, 06:30 PM | #7 | ||
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Guest
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Still, you have to be carefull with your judgements. Isradipine is not meant to relieve your symptoms. You are not going to get more dopamine or more dopamine neurons when taking this. It is supposed to be neuroprotective, which means that it's purpose is to slow the progression of your disease. It is not possible for you guys to know whether it has slowed down your disease progression. In fact, I think even the best researchers can't really show this because they lack biomarkers. The only way researchers are ever going to know if something is neuroprotective without biomarkers, is if the neuroprotectiveness is really spectacular.
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07-02-2012, 09:47 AM | #8 | |||
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Senior Member
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Quote:
Jean |
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