[olsen]

http://www.dailyrx.com/news-article/...lts-19430.html

A very small trial of an experimental vaccine has shown enough success and safety to encourage researchers to continue testing it with a larger group of people.



The aim was for those receiving the vaccine to develop an antibody response to beta-amyloid, a substance that builds up as plaque in the brain and kills brain cells.

It's formed by the breaking down of a protein in the outer membrane of nerve cells, and researchers hope a vaccine that prevents the build-up of beta-amyloid may also stave off Alzheimer's disease.

The study participants, aged 50 to 80, had mild-to-moderate Alzheimer's disease and were split into two groups for a study period lasting a year.

In one group of 31 patients, 24 received 50μg of CAD106 and seven received a placebo. In the second group of 27 patients, 22 received 150μg of CAD106 and five received the placebo...



In the first group, 67 percent of the patients receiving the vaccine developed the antibody response the researchers were looking for. In the second group, 82 percent of the CAD106-treated participants had the antibody response. One person who received the placebo had the antibody levels as well.

It will require long-term follow-ups to see if the antibody response results in actually reducing or preventing beta-amyloid and whether this prevents the deterioration of the disease...


The researchers concluded that CAD106 appears to be safe so far and leads to an antibody response in a substantial number of those who received the shot.

The study appeared online June 6 in the journal Lancet Neurology. The study was funded by Swiss pharmaceutical company Novartis.

I dont expect this to be a miracle cure. Disease-modifying ... YES ... a cure ... NO. 10 years ago a vaccine like this was already tested: http://ukpmc.ac.uk/articles/PMC28256...NEHAu230I0pv.0. The trial had to be stopped because 6 % of people got big troubles. Some of them even died. In the end 20 % of the people had no compliactions AND antibodies. Dementia was slowed down BUT in the latest days of their lives they died being very dement. So I guess these plaques do contribute to dementia but they are not the main cause of dementia. I don't understand why scientist pretend like this will be the big cure for Alzheimer. Is this in order for them to be able to get as much as patients possible for clinical trials ? Maybe a better cure would results from combining this vaccine with the ceregene gene therapy for AD; in case the clinical trials from ceregene prove to work of course.

I think (and also hope) the parkinson vaccine could be more promising as it was shown in computer simulations that misfolded a-synuclein attacks the neurons. Also, inserting misfolded a-synuclein in mice resulted in the mice developing parkinson as the a-synuclein started to attack the neurons of the mice. I also read today that this a-synuclein enters the neuron and blocks dopamine. Though I have my big questions mark about the vaccine also targeting non-harmful a-synuclein. Also, in combination with neurotrophic factors I think PD could be slowed down a lot. But of course, this is intuiton; nothing is proven yet. But I guess at least there is some good and not unrealistic hope.

[lurkingforacure]

We already know LPS can and has induced PD in a 22 year old, see here:

http://neurotalk.psychcentral.com/thread171246.html

Why folks don't try some antibiotic or the like, just to try, is beyond me, particularly when you consider how many PWP report incredible reduction of symptoms when on an antibiotic for something else, like tooth infection, etc. True, these are trials of one, and anecdotal, but I have read on a couple of forums of more than a few PWP whose symptoms significantly abate or outright disappear when on an antibiotic, only to return once the antibiotic has been discontinued. Seems like this would be an obvious thing to try, just to know one way or the other. But no real money in that, plus, it might actually cure folks, and they dont' want that, either.

Originally Posted by lurkingforacure

We already know LPS can and has induced PD in a 22 year old, see here:

http://neurotalk.psychcentral.com/thread171246.html

Why folks don't try some antibiotic or the like, just to try, is beyond me, particularly when you consider how many PWP report incredible reduction of symptoms when on an antibiotic for something else, like tooth infection, etc. True, these are trials of one, and anecdotal, but I have read on a couple of forums of more than a few PWP whose symptoms significantly abate or outright disappear when on an antibiotic, only to return once the antibiotic has been discontinued. Seems like this would be an obvious thing to try, just to know one way or the other. But no real money in that, plus, it might actually cure folks, and they dont' want that, either.

1. Where did you find out about antibiotics relieving symptoms ?
2. There is a clinical trial in which an antibiotic is being tested for its neuroprotectiveness. Look for the Creatine trial. This one is done together with some antibiotic.
3. What does your post have to do with the title of this thread ?

[lurkingforacure]

Originally Posted by Diego24

1. Where did you find out about antibiotics relieving symptoms ?
2. There is a clinical trial in which an antibiotic is being tested for its neuroprotectiveness. Look for the Creatine trial. This one is done together with some antibiotic.
3. What does your post have to do with the title of this thread ?

This forum, for one, I think it was Ron and also Peg who reported great improvement and/or cessation of PD while on antibiotics. There may be others on here as well. Other forums as well, just google it. Like I said, it's not something you read every day, I just noticed it because it seemed like more and more individuals made comments about feeling better when on antibiotics for this or that.

Creatine is not an antibiotic. Combining it with one is not the same as doing a trial with just the antibiotic. Results will be skewed by that which is a shame.

I take offense at your response. We are all trying to help each other here and share information. Sometimes we may throw something into a thread. That is what the search engine is for. Having to explain why you posted something where you did, particularly when there is the search engine, seems trivial, irrelevant, and useless to the overall purposes of the forum, IMHO.

Like most forums, take what you want and leave the rest. But please don't attack someone because you don't like where something was posted.

Originally Posted by lurkingforacure

This forum, for one, I think it was Ron and also Peg who reported great improvement and/or cessation of PD while on antibiotics. There may be others on here as well. Other forums as well, just google it. Like I said, it's not something you read every day, I just noticed it because it seemed like more and more individuals made comments about feeling better when on antibiotics for this or that.

Creatine is not an antibiotic. Combining it with one is not the same as doing a trial with just the antibiotic. Results will be skewed by that which is a shame.

I take offense at your response. We are all trying to help each other here and share information. Sometimes we may throw something into a thread. That is what the search engine is for. Having to explain why you posted something where you did, particularly when there is the search engine, seems trivial, irrelevant, and useless to the overall purposes of the forum, IMHO.

Like most forums, take what you want and leave the rest. But please don't attack someone because you don't like where something was posted.

Because some people on a forum claim to have beneficial effects that doesn't mean it will work. But, I do agree that if several people claim beneficial effects they should test this in preclinical trials.

I don't know whether the trial is the antibiotics mixed with creatine. Anyway, I don't really have the feeling the antibiotic being tested, is working. At least after the 2 clinical trials it seems the creatine is more promising than the antibiotics.

No problem with passing each other information. But why pollute a thread with something that has zero connection with the title? Just make another thread with the title "antibiotics". When I open a thread talking about ALZ vaccines I don't expect to read about antibiotics.

By the way, I am not attacking you. Why would I ? The discussion about antibiotics is interesting. But I think this should be done on a seperate thread.