(this is a reposting since i was unable to change the thread heading for the first posting. madelyn)

Urate as a predictor of the rate of clinical decline in Parkinson disea
http://f1000.com/1165821?referrer=GOOGLE

(abstract from 2009. Has anyone tried inosine?)
Urate and Parkinson's Disease

Higher concentrations of urate in the blood and spinal fluid of patients with early Parkinson's disease may be associated with slower rates of disease progression, according to a new study. Urate is an antioxidant that occurs naturally in the blood as an end product of normal metabolism.



A new trial is being launched to examine the effects of supplemental inosine (a precursor of urate) on the progression of Parkinson's disease. Until more evidence is available, experts are cautioning Parkinson's patients not to self-treat with inosine supplements. Too much urate in the body may increase the risks of kidney stones, gout and heart disease.



Ascherio A, LeWitt PA, Xu K, et al. Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol. 2009 Dec;66(12):1460-8. View Abstract

Olsen, this has also been posted already. Clinical phases are ongoing. I think phase II ends next year.

Just an FYI that there is no rule here that members cannot re-post something of relevance to the forum. Not everyone sees all the posts and so if someone chooses to make their own post about something that someone else may already have posted, that is absolutely ok, and there is no need to call them out on it.

I took inosine for a few months then awakened one morning with gross hematuria (blood in the urine.) There was no pain and the CT scans and other tests were negative. On the chance it was a uric acid stone (I felt something passing through the urethra,) I stopped the inosine.

GerryW, thank you for sharing your experience with inosine. We were discussing whether to experiment with this supplement. Given my husband suffered kidney stones from taking 2 doses 1 week apart of 50,000 IU's of D2 prescription (our conjecture) we will not try this one. (even though the pathway to kidney stones with megadose Vit D directly involves calcium and increased urate is associated with uric acid kidney stones) madelyn