http://bozemanchiropractic.com/bozem...etoxification/

I came to this detoxification thing when I found out about DOPAL. I didn't know about this, but I guess majority of you haev already heard of it as I saw a topic about it here, created in 2011. So my next step was to do a search for DOPAL in the Michael J Fox database. This is what I found:

https://www.michaeljfox.org/foundati...p?grant_id=520

The article claims that it could not be seen whether aldehyde dehydrogenase could prevent/ slow down PD in an animal model. They expected this to remove DOPAL, but the problem is that the way PD was created in this animal model doesnt generate the toxic DOPAL in the mouse brain. So they will now try to find a better animal model.

For me, this way of doing research is silly. They start from a hypothesis ... so they couldn't verify this, so they are gonna lose some years trying to find the perfect animal model and start all over again.

I think the MJ Fox foundation should start a clinical trial with this Alde-1. Why ? The experiments on the mice at least showed that it was not toxic to mice. Mice did get benefits from it in the symptoms department. In vitro showed that it removed DOPAL. So I think, in this case, the next steps towards a clinical trial could be started. I do realize they had a hypothesis and they couldn't test it properly. But despite that, it shows symptomatic improvements in mice that not even produce DOPAL. So it is worth trying it on people.

Usually I don't like to test meds early on people without enough proof of concept. But in this case, I think it is totally worth it as we know people with PD have 4 times more DOPAL, and DOPAL is known to be toxic to neurons. Moreover, it showed symptomatic improvement so in worst case it should be tested for symptomatic benefit.

[soccertese]

sorry, but i can't take any chiropractor seriously that puts out his theories on pd, especially when he posts "opinion" as in the following:
"Anecdotal Reasons Why Parkinson’s Disease is Probably IS Caused by Impaired Detoxification

If you have read this far, you understand that I do believe that Parkinson’s Disease is caused by impaired detoxification. There are two anecdotal observations that I have that fit this hypothesis.

First, Parkinson’s Disease patients commonly have a history of long-term exposure to some sort of toxic load. Smoking, agricultural chemicals, or even just solvents used in automotive repair.

Second, is the observation that Parkinson’s Disease patients who take L-Dopa seem to get worse faster. This makes sense, because L-Dopa increases Dopamine levels (improving symptoms in the short term), but the increased Dopamine levels means increases toxic DOPAL levels, speeding up the progression of the diseseae"
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first, smokers have less pd, there is no solid evidence l-dopa speeds up the progression as far as i know. toxins are likely a factor but genetics and other factors must be more important since the incidence of pd is so low and you don't see it in geographic clusters, say in a workers at a pesticide plant. there might be some but not enough for me at least to say it's always a toxin causing non-heredity pd.

Originally Posted by soccertese

there might be some but not enough for me at least to say it's always a toxin causing non-heredity pd.

The guy says things that are not correct. What he says is not scientifically proven. But what you say also isn't scientifically proven and in my view doesn't make sense at all. Majority of PD patients have aggregated a-synuclein, which is almost sure to be toxic to neurons. So how you come to the conclusion that toxins do not play a role in PD is a mystery to me.

[soccertese]

i'm not a biochemist or scientist, just a layman, but i didn't say toxins weren't involved, just that environmental toxin sources may not always be at play, which the author stated. it could be neurons ability to remove "garbage" from the cell is reduced so the proteins get sequestered into lewy bodies, thus in-vivo "toxins" .
as with mohammad ali, it might be blows to the head which causes inflammation which damages the cells or just plain force of the blows.

i was mainly questioning the author's credentials to speculate as a healthcare professional, which could result in influencing patient care decisions, which i assume is why he wrote the article.

that was the main reason for my comment, not to debate the causes of pd. my apology.

I totally agree on the fact that he pretends to be a scientist while he is not. Actually, I was just looking for DOPAL and then I came to this article and I put my attention on it because he claims there are some products that stimulate aldehyde dehydrogenase. Don't know whether his information is correct, though. Probably not . Anyway, the DOPAL topic is quite interesting. Let's just wait and hope on results from the MJFox foundation concerning meds targeting DOPAL.