I post this thread, because I wanted to discuss about Alpha-synuclein and whether it's clumping is present in ALL PD patients. A few days ago in some thread I don't remember anymore I had a discussion about it with a member (I think it was Conductor71). I told her that I read somewhere that alpha-synuclein is present in almost all PD patients, but I couldn't find the source. Now, by coincidence, I found the source. Here it is:

http://www.shakeitup.org.au/genetics...ad-the-charge/

MJFF is devoting the lion’s share of its gene-based investments to two of these targets: LRRK2, the most common genetic contributor discovered to date, and alpha-synuclein, whose clumping is seen in every case of PD.

I realize that scientist might make a mistake and not really ALL patients have this, because they can't know this for each patient. But, it seems to me that majority of PD patients must have this problem. Else they would have probably found post-mortem brains without misfolded a-synuclein.