I mentioned in a previous post about sinemet CR and my much better results after going back to regular sinemet. The difference: Sinemet CR shaking and tremor-medium off versus reguar Sinemet with relief of symptoms at same mg dose for 2.5 hours. Both doses wear off about 30 minutes early during most of the day. I googled pharmacokinetics of sinemet.

http://www.ncbi.nlm.nih.gov/pubmed/2685649

http://www.parkinsons-information-ex...rugdb/028.html

Just a thought for those having off wear-off's. It might help. Of course do this with a doctor's advice. These are dangerous drugs when doses change.

My doc thought CR would make my off's better and it actually extended them to being ineffective and me needing to bump doses 1/4 pill between doses. It seems, at least for me and some others, that some of us don't get a full dose using CR or ER. If we're taking meds every 3 hours anyhow and this takes 3 hours avg to metabolize then there is really no need for it is some people.

I was looking for decay curves. I do know that the makers ambien changed their drug to ambien CR to get around the patent laws and maintain a profit when the regular version went generic. My doc at the time told me the decay curves (of drug in blood volume) were almost identical. The difference was minimal enough by law to qualify as a new drug worthy of a new patent. I wonder if that is part of the issue with many drugs we take.