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09-06-2012, 02:59 PM | #11 | |||
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For this reason that my values had a fluctuating trend. Liposomal chelation, in my opinion is much less efficient. It's still very important as an aid to IV. Have you watched the videos of the previous post, what do you think?
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Sim00 Born in 1969, diagnosed PD in 2007, first symptoms 2004. DBS in July 2016. Last edited by sim00; 09-07-2012 at 01:33 AM. |
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08-09-2013, 06:25 AM | #12 | ||
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There is much interest at the moment in the role of alpha-synuclein in the pathogenesis of PD. I thought it would be interesting to go through my posts, most of which were based on epidemiological evidence, and see if there were any evidence of an involvement of alpha-synuclein.
Munishkina et al. [1] write: "Certain metals lead to increased risk of Parkinson’s disease (PD) and the aggregation of α-synuclein is implicated in the PD pathology. Although α-synuclein fibrillation has been extensively studied in dilute solutions in vitro, the intracellular environment is highly crowded. We are showing here that certain metals cause a significant acceleration of α-synuclein fibrillation in the presence of high concentrations of various macromolecules mostly through decreasing the fibrillation lagtime. The faster fibrillation in crowded environments in the presence of heavy metals suggests a simple molecular basis for the observed elevated risk of PD due to exposure to metals." Tag johnt:alpha-synuclein References: [1] "CONCERTED ACTION OF METALS AND MACROMOLECULAR CROWDING ON THE FIBRILLATION OF α-SYNUCLEIN" Larissa A. Munishkina, Anthony L. Fink, and Vladimir N. Uversky Protein Pept Lett. 2008 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677187/ John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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