I wonder if the body ever stops responding to levodopa. I have seemed to find a somewhat consistent timing and dosage of my levodopa (generic by Teva) that I can be relatively stable at w/o dyskinesia or a great amount of off time. Believe it or not if I do feel off or a little bit stiff I have confidence that it is just a while and my body will respond. In thinking of the long term does the body ever stop responding to levodopa. My reasoning is surely I will have to increase the dose as time goes on but does the body ever NOT respond to the med? I guess that you could probably reach a point where the slightest bit of overmedication would cause dyskinesia but that is a response-No? So do you ever develop non responsive Parkinson's where you are just off? Wouldn't want to find out.
For those that are wondering I take 1 1/2 25/100 when I get up then 1 tab every hour. It's a little bit at a time and I stay loose and dont get dyskinetic. My thinking is the medication stays in my body for about an hour. So in the morning I "prime" my body with an hour and half's medication. Then I maintain that level throughout the day. I use the alarm on my phone. I don't have the ups and downs of a roller coaster as if I were trying to spread out the doseage.

This only seems to make sense. A little bit at a consistent level. Duh? I have even gone out on short errands and forgot my walker at home. It is a little bit harder to keep up with the pills and alarms but I got used to it. When the alarm goes off I take a pill and erase that alarm. If I am wondering
"did I take that pill or not", which seems to be the biggest problem, I look to see if the alarm has been erased. I also have a daily diary icon on my phone where I log in 0930 and put xxx's for the 930 medication. Hey, it works for me. Another benefit I have found is that I pretty much don't have to worry about what I eat, the next dose is only at most an hour away.