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Mechanism That Leads to Sporadic Parkinson’s Disease Identified

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Old 09-25-2012, 02:49 PM #1
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Default Mechanism That Leads to Sporadic Parkinson’s Disease Identified
http://www.healthnewsdigest.com/news...entified.shtml
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"Thanks for this!" says:
anagirl (09-25-2012), johnt (09-25-2012), olsen (09-25-2012), Pops007 (10-03-2012), sim00 (09-25-2012)

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Old 09-25-2012, 04:19 PM #2
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Default Great news
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Originally Posted by soccertese View Post
Hi Soccertese,
thanks a lot to report this beautiful news.
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Born in 1969, diagnosed PD in 2007, first symptoms 2004. DBS in July 2016.
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Old 09-25-2012, 06:51 PM #3
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I am very happy to see again some research pointing at alpha synuclein. There are many agents entering clinical testing that intend to remove this protein. This is hope giving.
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Old 09-25-2012, 08:30 PM #4
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In the article referenced by Soccertese:

'“Furthermore, we found that exposure to toxins associated with Parkinson's can increase the abundance of this longer transcript form of alpha-synuclein. Thus, this mechanism may represent a common pathway by which environmental and genetic factors impact the disease,” said Dr. Abeliovich.'

This is consistent with my take on the spatial epidemiological data:
- people onset younger in "bad" areas.
- people progress faster in "bad" areas.

John
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