[CarolynS]

It has been a very very long time since I posted here...but my need is great...

I have to say first, yes, I know Reglan is a no-no for Parkinson's disease patients.

I am looking for an alternative to Reglan, which to my knowledge, is the only Gastroparesis drug therapy on the market.

It all started with my complaint that I was having swallowing problems (crackers, meat, etc.,) and as I should have, I sought medical advice before neurological advice, even though I knew the answer.

Jumping to the end of the story, I have bad Gastroparesis; e.g. dinner from 13/14 hours prior to endoscopy was still in my stomach and my stomach was inactive. This will not end well for me. As PWP, there is the complication that the known drug therapy is a non-no, and as a person with diabetes there is the issue of very bad glucose fluctuations, so I may end up on regular insulin after meals (Humalog), rather than my current synthetic, Lantus in the a.m. And, a totally liquid diet...ugh!!

Then, there is the reaction of a PWP friend, which was true and I know it, "Oh goodie, you get to starve to death." And, they say that PD doesn't kill us.

If you have have any advice on therapy alternatives that have worked for you, please reply. I don't see my MDS until the end of November.

Thanks,
Carolyn

[ol'cs]

Zofran instead of Reglan for nausea.. Simple to split short carbohydrates to augment direct absorption from first pass portal vein, and a little known "trick" to stimulate the pyloric valve; lie on back with head elevated and tap your torso where the ribs diverge. If you hear gurgling, you can be sure the pyloric valve is not blocking the passage of chyme. For caloric dense foods, use things that contain a lot of unsaturated vegetable fats such as olive oil and avocados. This might be a load of hooey in your case, but give it a try, you just might benefit, and I don't think it can hurt any.

[reverett123]

1- Ginger works for me. Go to PubMed. Some Chinese(?) research backs it up too.

2- Within the last week, Science Daily had a report on electrical stim of acupuncture points was very effective on this too.

Try the ginger first though. Rick

[CarolynS]

Thanks for the suggestions. I will check them out.

Carolyn

[pegleg]

Reglan is hell to PWP! It cancels any efficacy of PD meds. I only let that happen once. There's a much closer connection between the gut and neurological problems than scientists want to admit.

Good luck on finding a good medication.

Peg

[olsen]

Enhancing Parkinson’s Disease Symptom Improvement and Decreasing Adverse Event Incidence from L-DOPA Therapy by Improving L-DOPA Bioavailability and Consistency of Absorption through Co-administration of the Motilin Agonist, GSK962040


GRANT ABSTRACT

Objective/Rationale:
Parkinson’s disease often results in slower than normal emptying of food and medications from their stomach. This delayed gastric emptying is estimated to affect 50-90% of Parkinson’s disease patients. L-DOPA is absorbed when it reaches the upper intestine. If gastric emptying is delayed, L-DOPA may be erratically absorbed resulting in slowing to relief of patient symptoms and contribute to “on-off fluctuations.” GSK962040 is a new medication which in research studies has been shown to increase the speed at which the stomach empties. This project will study the effects of GSK962040 in people with Parkinson’s and delayed gastric emptying.

https://www.michaeljfox.org/foundati...?grant_id=1043