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11-17-2012, 01:15 AM | #1 | ||
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Magnate
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"Thanks for this!" says: | sim00 (11-19-2012) |
11-17-2012, 02:31 AM | #2 | |||
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Thls could prove to be fantastic please help follow it
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11-17-2012, 09:45 AM | #3 | |||
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Senior Member
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Is the protein identified? thanks, madelyn
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11-17-2012, 10:22 AM | #4 | ||
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Magnate
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Dr. Shannon: Right. We have a small group of patients with Parkinson's disease, 10 with very early Parkinson's disease, and then we compared them to 23 people who do not have Parkinson's disease. We only found the protein in the people who do have Parkinson's disease and we found that in every one of the people with Parkinson's disease.
http://www.newschannel5.com/story/20...-to-parkinsons |
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"Thanks for this!" says: | olsen (11-18-2012) |
11-17-2012, 10:26 AM | #5 | ||
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earch Article
Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease†‡§ Kathleen M. Shannon MD1,*, Ali Keshavarzian MD2, Ece Mutlu MD2, Hemraj B. Dodiya MS3, Delia Daian2, Jean A. Jaglin RN1, Jeffrey H. Kordower PhD3 Article first published online: 15 JUL 2011 DOI: 10.1002/mds.23838 Copyright © 2011 Movement Disorder Society Issue Movement Disorders Movement Disorders Volume 27, Issue 6, pages 709–715, May 2012 Additional Information(Show All) How to CiteAuthor InformationPublication History † Funding agencies: The study was supported in part by a research grant from Mr. and Mrs. Larry Field and by the Parkinson Disease Foundation. ‡ Relevant conflicts of interest/financial disclosures: Nothing to report. § Full financial disclosures and author roles may be found in the online version of this article. SEARCH Search Scope Search String Advanced > Saved Searches > ARTICLE TOOLS Get PDF (761K) Save to My Profile E-mail Link to this Article Export Citation for this Article Get Citation Alerts Request Permissions More Sharing ServicesShare|Share on citeulikeShare on connoteaShare on deliciousShare on www.mendeley.comShare on twitter |
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11-17-2012, 03:25 PM | #6 | ||
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Quote:
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11-17-2012, 04:40 PM | #7 | ||
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Magnate
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Quote:
http://ceregene.com/science_parkinsons.asp prosavin, pg 17 http://www.parkinsonsmovement.com/wp...ue-2-final.pdf nothing close to being available though. but as cliche as it sounds, the research is advancing by leaps and bounds. am i hopeful in my 12th year for something better than duodopa or dbs before i'm too old?? yes. so one has to live their life and take care of themselves the best they can so they can get whatever that "cure" may be. they've already proven with foetal implants that in the best outcomes, the patient will experience sig. improvement for years. the procedure had some terrible outcomes and because of that and the ethics of using aborted fetuses, research was stopped. but don't let anyone tell you advanced pd'ers can't be helped by cell implants, they have been. at least that's been my understanding. |
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11-17-2012, 08:58 PM | #8 | ||
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Senior Member
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So how does the a-syn get out of the gut into the brain, past the bbb?
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11-17-2012, 10:40 PM | #9 | |||
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LFAC,
I've think people like Braak have suggested retrograde transport via nerves connecting the gut and brainstem such as the vagus. Also, movement between cells prion-like may be involved (e.g. across synapses; post-to-pre). Lewy bodies are already inside the BBB in gut ganglia. Perhaps the real mystery is ...What causes aggregated alpha-syn to form in those ganglia in the first place? |
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11-17-2012, 10:43 PM | #10 | ||
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Quote:
Do you still remember not long ago AFFiRi AG's vaccine and also QR Pharma's Posiphen? At first the intestinal link was just an assumption, now, it is a "dream"(bad dream or a nightmare) comes true. But I have not heard about their trials ever since then, as I think they should in some way work together. From my internet readings, I have a feeling that researchers may not talk to each other and collaboration is limited. Many exchanges are only made at seminars or annual conferences where you possibly only have a small slice of time... On the other hand I think MJFF did great job as to fund all these studies, or this may still be a "dream" till now... |
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