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01-31-2013, 03:54 PM | #1 | ||
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Magnate
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http://www.parkinsonswny.com/Parkinson-Handbook.pdf
2004 date but a lot of stuff in there i didn't know. some things out of date. Because of the nausea many patients experience when taking levodopa alone, it is usually taken in combination with carbidopa (trade name: S i n e m e t). This nausea is caused by the conversion of levodopa to dopamine in the intestine and blood before levodopa reaches the brain, and by direct stimulation by levodopa of the vomiting center in the brain. Carbidopa blocks the conversion of levodopa to dopamine only in the intestine and blood (not in the brain) and thereby markedly reduces the incidence of nausea and vomiting. It also ensures that more levodopa goes into the brain and is not wasted by conversion to dopamine in the blood or intestine. Patients taking the combination, therefore, require less levodopa per dose than if they take levodopa alone. For these reasons it is the most common form in which patients take levodopa. Levodopa/carbidopa comes in two forms, s t a n d a r d and c o n t r o l l e d - r e l e a |
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