Parkinson's Disease Tulip


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Old 03-28-2013, 10:33 AM #1
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default patch pump for carbidopa/l-dopa might work but years away

certainly less cost/risk than duodopa? but years away from commercialization - must inject pretty small doses since i've read l-dopa is irritating:
"Where to Infuse
Levodopa is poorly soluble in water, making it impractical for outpatient
or ambulatory use. Furthermore, it is irritating to veins and soft tissues,
ruling out long-term intravenous or subcutaneous administration. The
current solution is the gel formulation, used in Duodopa, which reduces
the volume of infusate 10-fold, and as it includes carbidopa eliminates
the need to take additional oral medications. By delivering straight to the
duodenum, Duodopa also avoids the problems of erratic gastric emptying
and interference from food boluse"
http://www.touchbriefings.com/pdf/3009/Mouradian.pdf

http://www.redorbit.com/news/health/...se-i-study-of/
http://www.intrapump.com/crono_five.html
http://clinicaltrials.gov/ct2/show/N...uroderm&rank=2
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