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03-28-2013, 10:33 AM | #1 | ||
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Magnate
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certainly less cost/risk than duodopa? but years away from commercialization - must inject pretty small doses since i've read l-dopa is irritating:
"Where to Infuse Levodopa is poorly soluble in water, making it impractical for outpatient or ambulatory use. Furthermore, it is irritating to veins and soft tissues, ruling out long-term intravenous or subcutaneous administration. The current solution is the gel formulation, used in Duodopa, which reduces the volume of infusate 10-fold, and as it includes carbidopa eliminates the need to take additional oral medications. By delivering straight to the duodenum, Duodopa also avoids the problems of erratic gastric emptying and interference from food boluse" http://www.touchbriefings.com/pdf/3009/Mouradian.pdf http://www.redorbit.com/news/health/...se-i-study-of/ http://www.intrapump.com/crono_five.html http://clinicaltrials.gov/ct2/show/N...uroderm&rank=2 |
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