Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 04-12-2013, 01:17 AM #1
lwlw lwlw is offline
Junior Member
 
Join Date: Feb 2013
Location: Small village in Pen Llyn North Wales
Posts: 7
10 yr Member
lwlw lwlw is offline
Junior Member
 
Join Date: Feb 2013
Location: Small village in Pen Llyn North Wales
Posts: 7
10 yr Member
Default sinemet low dose giving side effects

Just been put on sinemet 12.5 so that I can lower ropinirole slow release tabs ,am now on 16mg of rop .
Symptoms of pd got worse , walking not as good . Got in touch with Parkinson nurse she said to add from 1 sinemet 3 times a day to 2 x 3 times a day , doing this gradually , which I have .

I am at the moment taking 2 in morning , 1 lunch and 2 in evening ,
to my family s amazement My facial expression s are exaggerated when talking ,I do a lot of silly expressions which is not like me !!!! My speech is mumbled and Im constantly moving ,not sudden twitching just hand on my face or through hair for example.

Has anyone else gone through this or just me , is it because my body hasn't adjusted to new drug , I am doing it slowly .
I know sinemet has side effects ,but suerly not on such small dose.

Any help or suggestions would be appreciated
lwlw is offline   Reply With QuoteReply With Quote

advertisement
Old 04-12-2013, 02:36 AM #2
made it up made it up is offline
Member
 
Join Date: Oct 2006
Posts: 376
15 yr Member
made it up made it up is offline
Member
 
Join Date: Oct 2006
Posts: 376
15 yr Member
Default

Quote:
Originally Posted by lwlw View Post
Just been put on sinemet 12.5 so that I can lower ropinirole slow release tabs ,am now on 16mg of rop .
Symptoms of pd got worse , walking not as good . Got in touch with Parkinson nurse she said to add from 1 sinemet 3 times a day to 2 x 3 times a day , doing this gradually , which I have .

I am at the moment taking 2 in morning , 1 lunch and 2 in evening ,
to my family s amazement My facial expression s are exaggerated when talking ,I do a lot of silly expressions which is not like me !!!! My speech is mumbled and Im constantly moving ,not sudden twitching just hand on my face or through hair for example.

Has anyone else gone through this or just me , is it because my body hasn't adjusted to new drug , I am doing it slowly .
I know sinemet has side effects ,but suerly not on such small dose.

Any help or suggestions would be appreciated
Hi lw and welcome.
Sounds like it could be dyskinesias you're experiencing with the constant moving. I'm guessing a bit here but does it come across as a kind of restlessness to others?
Do you feel at this stage you need that amt of levodopa or could you perhaps take a little less than what was recommended?
Also do you have young onset parkinsons?
I found I got dyskinesic very soon after commencing Sinemet but as PD progressed I preferred that to the offs.
DBS several yrs ago for me hasn't seen a return of any dyskinesia and I take a reduced amt of meds so hang in there ok?
made it up is offline   Reply With QuoteReply With Quote
Old 04-12-2013, 08:33 AM #3
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default

what is sinemet 12.5? how many milligrams of levodopa are you taking/day?
if that's 12.5mg i doubt you are taking enough to even get any into your brain.
how much requip are you still taking? from what i've read, you normally slowly dose up on sinemet and slowly wean yourself off the agonist.
when were you diagnosed?
how old are you?
what was your first total daily dose of sinemet in milligrams when first prescribed?

just curious, why are you switching?
soccertese is offline   Reply With QuoteReply With Quote
Old 04-12-2013, 05:00 PM #4
made it up made it up is offline
Member
 
Join Date: Oct 2006
Posts: 376
15 yr Member
made it up made it up is offline
Member
 
Join Date: Oct 2006
Posts: 376
15 yr Member
Default

Quote:
Originally Posted by soccertese View Post
what is sinemet 12.5? how many milligrams of levodopa are you taking/day?
if that's 12.5mg i doubt you are taking enough to even get any into your brain.
how much requip are you still taking? from what i've read, you normally slowly dose up on sinemet and slowly wean yourself off the agonist.
when were you diagnosed?
how old are you?
what was your first total daily dose of sinemet in milligrams when first prescribed?

just curious, why are you switching?
Soccertese, hi
I assume it's a typing error and was meant to say 120/25 mg.
Is that right lw?
made it up is offline   Reply With QuoteReply With Quote
Old 04-13-2013, 02:59 AM #5
lwlw lwlw is offline
Junior Member
 
Join Date: Feb 2013
Location: Small village in Pen Llyn North Wales
Posts: 7
10 yr Member
lwlw lwlw is offline
Junior Member
 
Join Date: Feb 2013
Location: Small village in Pen Llyn North Wales
Posts: 7
10 yr Member
Default

hi , the dosage on box says 12.5 mg/50mg carbidopa and levodopa sinemet, very small dose an introduction to the drug , then increase from 1 3 times a day to 2 3 times a day, but as soon as I took 2 morning 1 lunch and 2 evening the side effects began , on such low dose !!! My speech slurred and facial expressions were allover the place .
I am 42 diagnosed 5 years .
Parkinsons nurse visited Friday , going to try Madopar as this has different drug to sinemet to help release in body .
Anyone else had same problem
lwlw is offline   Reply With QuoteReply With Quote
Old 04-13-2013, 04:48 AM #6
Ronhutton's Avatar
Ronhutton Ronhutton is offline
In Remembrance
 
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
15 yr Member
Ronhutton Ronhutton is offline
In Remembrance
Ronhutton's Avatar
 
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
15 yr Member
Default

Hi Madeitup,/Soccertese,
Levodopa decomposes in the body before it gets to the brain, by what is called a decarboxylation reaction, (loss of carbon dioxide) forming dopamine.
Carbidopa is added to the tablets to stop this side reaction. If you use a 50mg Sinemet tablet it is labelled 62.5 which means 50mg levodopa and 12.5 of carbidopa.

I have been able to reduce my sinemet to around 75 to 150 mg of levodopa
as I have become extremely sensitive to levodopa. At this level, I still suffer terrible dyskinesias with a half 50mg tablet, ie 25mg levodopa. Strangely
eating seems to trigger the start of dyskinesia
I am sorry I don't have a solution to the dyskinesia problem, I only wish I had.
Ron
__________________
Diagnosed Nov 1991.
Born 1936
Ronhutton is offline   Reply With QuoteReply With Quote
Old 04-13-2013, 10:29 AM #7
moondaughter's Avatar
moondaughter moondaughter is offline
Member
 
Join Date: Jul 2010
Location: rural Eastern Oregon
Posts: 613
10 yr Member
moondaughter moondaughter is offline
Member
moondaughter's Avatar
 
Join Date: Jul 2010
Location: rural Eastern Oregon
Posts: 613
10 yr Member
Default does everything have to be so complicated?

[QUOTE=Ronhutton;974640]
I am sorry I don't have a solution to the dyskinesia problem, I only wish I had.
Ron[/QUOTE

http://neurotalk.psychcentral.com/thread171294.html

These blue lensed glasses help....
__________________
Smooth seas do not make skillful sailors....
Nature loves courage.


“The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.”
~ Nikola Tesla
moondaughter is offline   Reply With QuoteReply With Quote
Old 04-13-2013, 01:28 PM #8
reverett123's Avatar
reverett123 reverett123 is offline
In Remembrance
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
reverett123 reverett123 is offline
In Remembrance
reverett123's Avatar
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
Default Nicotine still an option

Ron-
I know that this was discuss`ed a time or two according to the archives, but I don't recall anyone really giving it a trial. It might be worth looking at. It seems that smoking would be superior to the patches - more control and you can get the good Cuban forms.


Expert Review of Clinical Pharmacology
Can Nicotine be Used Medicinally in Parkinson's Disease?

Claire Thiriez, Gabriel Villafane, Frédérique Grapin, Gilles Fenelon, Philippe Remy, Pierre Cesaro
Disclosures

Expert Rev Clin Pharmacol. 2011;4(4):429-436.

http://www.medscape.com/viewarticle/746713
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
reverett123 is offline   Reply With QuoteReply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Lower gabapentin dose: how long before side effects relent dac122 Peripheral Neuropathy 1 09-25-2012 10:33 AM
drug-interactions-side-effects/Clonazepam-Klonopin-Vicodin-Sinemet-Lipitor- lou_lou Parkinson's Disease 0 06-01-2012 06:42 AM
Improved Sinemet Dose and Timing Atma Namaste Parkinson's Disease 10 01-31-2012 05:00 PM
i'd like to know about personal sinemet side effects paula_w Parkinson's Disease 5 11-30-2011 07:43 PM
Sinemet side effects njmama09 Parkinson's Disease 5 11-28-2011 11:20 AM


All times are GMT -5. The time now is 06:52 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.