[GerryW]

Serum cholesterol and the progression of Parkinson's disease: results from DATATOP.

http://www.ncbi.nlm.nih.gov/pubmed/21853051

I have always had low cholesterol (160) and I wonder if that had something to do with this affliction. Anyone else with low cholesterol?

[anagirl]

Originally Posted by GerryW

Serum cholesterol and the progression of Parkinson's disease: results from DATATOP.

http://www.ncbi.nlm.nih.gov/pubmed/21853051

I have always had low cholesterol (160) and I wonder if that had something to do with this affliction. Anyone else with low cholesterol?

Interesting.... I've always had low cholesterol also. Thanks for posting.

[Tupelo3]

I also have very low cholesterol. Although the study seems to focus on progression for PWP. Not sure how that relates to the actual occurrence of PD.

Does this mean it's time to change diets and bring on the bacon cheeseburgers?

[olsen]

http://www3.interscience.wiley.com/j...39643/abstract

Letter to the EditorReply: Plasma cholesterol and Parkinson's disease: Is the puzzle only apparent?
Xuemei Huang 1 *, Honglei Chen 2, Helen Petrovitch 3, Richard Mailman 4, Webster Ross 3 1Department of Neurology, Penn State University College of Medicine,

Letter Reply:
Plasma Cholesterol and Parkinson's Disease: Is the Puzzle Only Apparent? Our first publication ...reporting an association between lower cholesterol and Parkinson's disease (PD) noted the limitations of case-control analysis. It cautioned the readers that we could not make a causal inference between LDL-C and/or statin use and risk of PD.[1] To reduce the possibility of reserve causality, we subsequently studied a prospective cohort[2] and found a similar association. Similar findings were also reported in two other prospective cohorts.[3][4] Interestingly, Scigliano...[et al]... found the association of untreated IPD with reduced vascular diseases risk(s) including higher cholesterol.[5] There has been one inconsistent report[6] in which the cases were identified from a National Insurance Register that entitles patients to medication free of charge. Therefore, the overall evidence to date favors an association between higher cholesterol and lower PD occurrence... Rigorous diagnostic criteria[7] were applied in the Honolulu Asia Aging Study.. Further, the age of onset in any study population is bounded by its age distribution. The average age at cholesterol assay in the Honolulu cohort was 77 years old,[2] thus, it is not surprising that the onset of incident cases was also higher in this cohort. Given the consistency of ...[these]... studies, it seems to us that more, not less, research should be conducted to understand the nature of this finding and its medical ramifications, if any. Thus, we disagree with Scigliano et al.'s notion that future studies should simply be abandoned. It is both inconsistent with the weight of available evidence, and contrary to the scientific method.

[lurkingforacure]

Almost every pwp I know has "low" cholesterol. We are early onset and have always had low cholesterol, waaaay before PD dx. And I don't mean just a little lower, but significantly lower, to where the doctor says "great, come back in five years, no worries here". Lots of folks with the same story, and ditto for vitamin D3 levels, that seems to be commonly low in PWP as well.

[kukai8]

I, too, have always had low levels of cholesterol.

See vitamindwiki and grassrootshealth for up-to-date information suggesting a relationship - now being analyzed through clinical trials - among naturally variable cholesterol levels in human beings, serum vitamin D3 levels and incidence of PD.

The information on these sites is also available at Pubmed and, in my opinion, is compelling.

My choice: to believe that daily ingestion of 10,000 International Units of vitamin D3 ( + cofactors described at vitamindwiki may help in slowing progression of my PD).

Vitamin D3 is a low-cost add-on to my self-directed therapy that also includes mucuna pruriens, ashwagandha, green tea and curcumin.

[kukai8]

I, too, have always had low levels of cholesterol.

See vitamindwiki and grassrootshealth for up-to-date information suggesting a relationship - now being analyzed through clinical trials - among naturally variable cholesterol levels in human beings, serum vitamin D3 levels and incidence of PD.

The information on these sites is also available at Pubmed and, in my opinion, is compelling.

My choice: to believe that daily ingestion of 10,000 International Units of vitamin D3 ( + cofactors described at vitamindwiki) may help in slowing progression of my PD.

Vitamin D3 is a low-cost add-on to my self-directed therapy that also includes mucuna pruriens, ashwagandha, green tea and curcumin.

[Canna]

Mine is elevated and still is though I quit eating animal protein a year ago.