Parkinson's Disease Tulip


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Old 05-02-2007, 10:13 AM #1
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Default Riding A Bike to Treat PD?

I don't know if any of you heard about this. This was a news story on our local TV newscast yesterday.

IMAGINE IF THE BEST TREATMENT FOR PARKINSON'S DISEASE TURNED OUT TO BE AS EASY AS RIDING A BIKE.

THE CLEVELAND CLINIC IS CONDUCTING A STUDY THAT IS TRYING DETERMINE IF EXERCISE CAN TRICK THE BRAIN INTO ELIMINATING PARKINSON'S SYMPTOMS.


FOR NINE YEARS, STEVE DERMAN FOUGHT PARKINSON'S DISEASE. LIKE MOST, HE SUFFERS FROM TREMORS UNTIL HE TAKES A RIDE.

(SOT: Steve Derman, Parkinson's Patient)
"The exercise just seems to help my mind as well as my body."

HE'S PART OF A STUDY TESTING THE EFFECT OF EXERCISE ON PARKINSON'S SYMPTOMS.

HE MUST PEDAL OVER EIGHTY R-P-M'S FOR RESULTS TO OCCUR. MOST PATIENTS CAN'T DO THAT ON THEIR OWN, THAT'S WHY A TANDEM BIKE IS USED. IT'S CALLED FORCED EXERCISE.

(SOT: Jay Alberts, Ph.D., Cleveland Clinic)
"The idea behind it is if we force them to pedal at a higher rate, this rate will allow them to have biochemical changes that are necessary for improvements in motor function."

STEVE'S LEGS MAY BE HELPING HIS BRAIN.

(SOT: Jay Alberts, Ph.D., Cleveland Clinic)
"There's a possibility that there's an increase in dopamine or there's a possibility that there's an increase in these neuro growth factors."

WHATEVER IT IS, IT SEEMS TO SLOW STEVE'S TREMORS FROM THIS ... TO THIS AFTER A FEW MINUTES OF CYCLING.

(SOT: Steve Derman, Parkinson's Patient)
"At least in my mind they did. Whether anyone else noticed it, I really don't care but at least I feel that it did."


"SO IF THE STUDY DETERMINES THIS IS A VIABLE TREATMENT OPTION, A PATIENT COULD HAVE A BIKE LIKE THIS IN THEIR HOME AND PEDAL WITH A FAMILY MEMBER."

AFTER EIGHT WEEKS, STEVE NOT ONLY GOT IN TO BETTER PHYSICAL SHAPE, RESEARCHERS NOTICED A CHANGE.


"His tremor was reduced his rigidity was reduced over the course of the study."

BUT THE BENEFITS ONLY LAST AS LONG AS THE PATIENT STICKS TO THE EXERCISE REGIMEN ... STEVE'S MORE THAN WILLING TO USE IT RATHER THAN LOSE IT.



THE STUDY IS COMPARING THE DIFFERENCE BETWEEN FORCED EXERCISE WITH A TANDEM BIKE TO A STATIONARY BIKE WHERE THE PATIENT PEDALS ON THEIR OWN.


Take it for what it's worth,

GregD
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Old 05-02-2007, 12:57 PM #2
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Default Forced Exercise

Hi Gregg,
I saw this one too. I thought what a daft idea to use a tandem with a friend or relative peddleing like fury to make your legs reach a certain revolution.
Surely the easiest way would be to motorise an exercise bike!!!
That way, you are not in peril from cars etc, you do not have to phone your friend daily to come and pedal the tandem, and so on.
With a motor fitted to your exercise bike, and a rheostat to vary the speed, you would be totally independant on others.
I have an exercise bike which I lent to my son. I want to get it back and try it.
Ron
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Old 05-02-2007, 02:18 PM #3
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Hi Ron,
My thoughts exactly. Also, I've been riding my exercise bike daily for the past 6 months to help control my weight. I have yet to see any reduction in my tremors. I'm sure it will be like everything else so far. It will work for some but not all.

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Old 05-02-2007, 03:55 PM #4
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Hi

I post on the peripheral neuropathy page. I have small fiber neuropathy and severe restless leg (all over body) for which I take Pramipexole...(not a small dose either.) I have been riding a bike more or less for 21 years. I have gone thru periods where I have stopped and I have deteriorated horribly. I was off my bike for a while when they put in a PICC line to give me steroids and then I really went down the tubes. My family lives and breathes cycling and my one daughter is a pro...(one of the few really clean pros-she knows the dangers of fooling with physiology-she is an environmental scientist as well). I am a nurse and a clinical exercise specialist.

I can not explain the exact phenomenon of why cycling works to keep my symptoms more or less in control, of course, my symptoms are not like typical parkinsons. I do however, have severe autonomic neuropathy as well as sensory neuropathy. I not only pedal around on a mountain bike or road bike, I do it to music in one ear only, and I ride in a dark tunnel to challenge my balance (somatosensory system). I stimulate every system, visual, vestibular and somatosensory.

I think some of the benefits have to do with stimulating dopamine and endogenous opioids. I can't run anymore due to desicated discs that require open chest surgery to fix, and I can't tolerate general anesthesia. I am a female, 54 and did my last sprint triathlon at 50....I canned competition for now, as I got so out of shape on steroids and needed almost 2 years to rebuild muscle lost to the treatment. I am not ruling it out as a possibility in the future. Bike trails are a great place to start, as they are flat and safer in terms of traffic. Get a stress test, as recommended before undertaking any new exercise regimen. I bring a cell phone, dog repelent spray, wear a camel back, as I am prone to plunging blood pressures, and I have global anhidrosis, do not sense temperature well, so I have to bring a variety of clothes and layers in unpredictable weather....I also don't feel myself sunburning, and I also have gastroparesis, so I have to sip water the whole time I am on the bike, as my stomach does not empty as it should leaving me feeling like I have a bowling ball in there.....but hey----it is worth every minute! Oh and bring a identification with your medical condition on it.

I highly recommend clipless pedals of the mountain bike variety, shoes you can walk on and shoes that clip in and keep your feet in position, but also release very easily. I wear mtn. bike clipless for my mtn. bike and road for my road bike, but if you have balance problems or gait problems road shoes will cause you problems. Toe clips that fit on regular shoes can make for a slow escape from a pedal, slower than a clipless pedal.....I recommend having several hand positions as well, and I have some adaptive (actually racing bars/aero bars) on my bikes. Proper bike fit is essential. My biggest urk, when I get off a bike or take my feet off even the feet of a chair....it feels like that is stuck in my foot for a half an hour afterwards....

I highly recommend cycling and if a regular bike won't due there are adaptable bikes and stationary bikes, both uprights and recumbents...there are even tandem recumbents...and lots of social opportunities. In my cycling adventures I have met a one legged cyclist who had crossed the Rockies (Lord I can't do that with 2 legs and one blind cyclist.)

Just wear a helmet, eye wear and gloves...padded shorts help too! Nothing like wind in your hair and bugs in your teeth to make you feel great! A bee down your shirt doesn't feel that great....but it happens.
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Old 05-02-2007, 03:56 PM #5
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Default biking

Hey guys,

I got a mountain bike for Christmas. I ride the trails on a reserve
close to my home. It has hills and small streams. I always feel
better after I ride. I don't know if it's improving my pd, but it is
easier than other types of exercise and it is good to get outside
and explore nature.

Mary
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Old 05-02-2007, 04:27 PM #6
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I wonder if a stair stepper would help in the same way. I have one that someone gave away in my laundry room in my building. It's like this one:

http://www.walmart.com/catalog/produ...de=cii_9324560

I hold on to the top of my secretary (furniture!) while I use it. I haven't used it much, but will do better. There's alot of resistance, and I think it may affect the same muscles as a bike.

This one is better because you can hold on:

http://cgi.ebay.com/New-Exercise-Wor...QQcmdZViewItem
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Old 05-02-2007, 04:50 PM #7
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INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 12: 485-492, 2003

Cyclic exercise induces anti-inflammatory signal molecule
increases in the plasma of Parkinson's patients

PATRICK CADET
1
, WEI ZHU
1
, KIRK MANTIONE
1
, MARILYN RYMER
2
, IRVING DARDI

It has been known for many years that immune
system alterations occur with Parkinson's disease (PD).
Changes in lymphocyte populations in cerebrospinal fluid
and blood, immunoglobulin synthesis, and cytokine and acute
phase protein production have been observed in patients with
PD. Hence, there is evidence for inflammation. In this report
we demonstrate that cyclic exercise over months results in a
significant increase in the rise of plasma anti-inflammatory
signal molecules, such as interleukin-10 and adrenocortico-
tropin. Additionally, endogenous plasma morphine levels
increase with the duration of the cyclic exercise protocol.
Morphine is identified and quantified by high performance
liquid chromatography coupled to electrochemical detection
and nano electro-spray ionization double quadrupole
orthogonal acceleration time of flight mass spectrometry.
Proinflammatory cytokine, i.e., interleukin-1, interleukin-6,
plasma levels did not increase. These results matched with
those reported previously, demonstrating enhanced motor
skills and mood elevation with this cyclic exercise protocol,
suggest that this protocol induces the formation of anti-
inflammatory signal molecules, which appear to be associated
with alleviation of some of the clinical characteristics of PD.
Introduction
Idiopathic Parkinson's disease is a degenerative disorder of
the central nervous system. Several pathogenic mechanisms
have been proposed that lead to degeneration of dopamin-
ergic neurons. These mechanisms encompass variables such
as metabolic or toxic factors, oxidative stress and mito-
chondrial dysfunction (1). The primary anatomical features
central to PD patients include: a diminished number of
myelinized dopaminergic cells in the substantia nigra (SN)
and in related brain stem nuclei, a decrease in the dopamine
content in nigrostriatal and mesolimbic pathways, the
presence of Lewy bodies, and the deposition of neuromelanin
(2,3). The perturbation of several neurotransmitters and
neuropeptides has been reported in PD, indicating a more
complicated and widespread pathology. The role of immune
and vascular mechanisms in neurodegenerative diseases such
as PD is, similarly, an important area of investigation (1,4).
Death or injury to neurons in PD leads to the presence of many
pro-inflammatory cytokine molecules, as well (1). This process
resembles classic inflammation, but with minimal or no
participation of macrophages and lymphocytes from blood (1).
In the present report, we determine the plasma level of
pro-and anti-inflammatory cytokines as well as signal mole-
cules most often associated with stress, i.e., adrenocortico-
tropin (ACTH) at baseline (group 1). We also measure these
levels subsequent to the introduction of a 12 week cyclic
exercise regime at week 4 (group 2), week 8 (group 3) and
week 12 (group 4). We demonstrate that anti-inflammatory
signal molecules significantly appear in the plasma months
after initiating and sustaining this cyclic exercise protocol.
These results are correlated with a previous study, which found
that cyclic exercise in Parkinson's patients produced
improvement in motor function and attitude


http://147.52.72.117/ijmm/2003/volume12/number4/485.pdf
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Old 05-02-2007, 07:08 PM #8
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Default rebounder anyone?

Somewhere along the line, I read something Dr. Lieberman wrote suggesting that the little trampolines called "Rebounders" are particularly good for PD. Has anyone had experience with them?

They would differ from a bike in several ways but one in particular would be that they "jiggle your innards". According to a book I'm reading called "The Second Brain" (about the nerves controlling the GI system), such jiggling causes a flood of several neurotransmitters which could account for a lot.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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Old 05-04-2007, 10:59 AM #9
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I just received some confirmation that my condition is not just a small fiber neuropathy, but likely has central nervous system involvement....and it seems to be a bit similar to MSA, but not as profound, as rapidly declining or quite as debilitating, as of yet or if ever....so I don't quite fit in either forum, or I fit in both...kind of like a high school clique, you know? I don't tremor, but the restless leg is body wide....I do have spasms, fasciulations, numbness, tingling, occassional loss of balance, and a fair amount of pain. I also have a lot of parasomnias and hideous insomnia. My autonomic neuropathy is subsantial. So far my cognition seems OK,but I notice I am not as sharp as I was, but I was pretty sharp mentally, so I have a way to decline before I worry too much.

On the cycling, all I can say is I started cycling at 34, got into citizen level competitive cycling, eventually into sprint triathlon, but by 50, had to hang up the sprint tri and competitive stuff, as adrenaline, seems to make my BP and pulse dump on me....I am 54 now.

I can tell you that for me, you can tell a day when I bike from a day when I don't. Running is fine, but with my problems it also causes problems....walking doesn't get me a 'walker's high'...swimming is OK, but does not for some reason have the same effect as cycling. Endogenous opioids do play a huge role in what ever ails me and I have to keep them coming....problem is, some days, dysautonomia keeps me from moving much...I have to really, really force myself, but it is always worth it.

A bicycle is a great equalizer. I think one of the key things is it stresses balance mechanisms, too. It also develops major muscles that affect gait and also blood return to the heart.

Somthing new to look at out there in the realm of research is Orexin and the hypocretin system. Very cutting edge and a way off, but on the far horizon.
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Old 05-04-2007, 06:22 PM #10
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Quote:
Originally Posted by reverett123 View Post
Somewhere along the line, I read something Dr. Lieberman wrote suggesting that the little trampolines called "Rebounders" are particularly good for PD. Has anyone had experience with them?

They would differ from a bike in several ways but one in particular would be that they "jiggle your innards". According to a book I'm reading called "The Second Brain" (about the nerves controlling the GI system), such jiggling causes a flood of several neurotransmitters which could account for a lot.

That's a really good idea. I'd need to hold onto something, though, since my balance is bad. I checked and they make them with something to hold on to. They call it a stabilizer. Makes sense.
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