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04-25-2013, 11:08 AM | #1 | |||
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Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease*
D. James Surmeier‡,1 and Paul T. Schumacker§ The most distinguishing feature of neurons is their capacity for regenerative electrical activity. This activity imposes a significant mitochondrial burden, especially in neurons that are autonomously active, have broad action potentials, and exhibit prominent Ca2+ entry. Many of the genetic mutations and toxins associated with Parkinson's disease compromise mitochondrial function, providing a mechanistic explanation for the pattern of neuronal pathology in this disease. Because much of the neuronal mitochondrial burden can be traced to L-type voltage-dependent channels (channels for which there are brain-penetrant antagonists approved for human use), a neuroprotective strategy to reduce this burden is available... http://www.jbc.org/content/288/15/10736.full
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"Thanks for this!" says: | moondaughter (04-26-2013) |
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