Our neuro told us recently that he could script lodosyn to make the sine met last longer....basically it is just more carbidopa...

Our question is: if more carbidopa helps extend the levodopa, why do they not script this when they first give you sine met? Why wait years, during which the levodopa may do collateral damage to tissues outside the brain, when they could just script some extra carbidopa to make sure more of that levodopa makes it to the brain before being broken down? And if it is because they do not want to make a smaller dose pill than 25/100, the smallest one I think, is that not just pure evil and greed to sell more drug than is necessary upon initial dx?

Why can they not make a mini-sinemet, just like there is for mirapex? We could start with 12.5/50 and go from there...

Does anyone know anything about lodosyn? Share your experience if you take or have tried it.

Take it with MP. What did you want to know? Comes in 25mg x 100 tablets per script. If you take it solo with MP you need less MP than if you take MP alone.

did your neuro spontaneously recommend this or did you bring it up? has he/she done this with other patients with success?

you'd have to go back and look at the old studies figuring out the half life of carbidopa and dosages.

you can easily split a 25/100.
doesn't stalevo come in small doses?
not sure what happens with a carbidopa overdose. is it worse than slightly too little?

i heard that before carbidopa was used, up to 16mg of l-dopa was administered,slowly titrated, with severe side affect as would be expected. so to get down to less than a gram needed there must have been a lot of research on carbidopa.

and remember, it's the other enzyme systems that break down dopamine in your brain that become more important as we progress imho, there are less neurons to store and protect the dopamine once it's converted.

i've also read that there is speculation that at high doses, carbidopa may pass the BBB. which is the last thing you want.

i wouldn't assume we can all benefit from more carbidopa based on one neuro.

http://www.ncbi.nlm.nih.gov/pubmed/16614536

It was on my request.