Perhaps this topic has already been discussed, here, but I felt it would be worth posting my harrowing experience with generic manufacturers. In all my years, this had never occurred to me UNTIL my pwp manifested horrific mental difficulties. Neither I nor her neurologist could imagine what happened to her...only that her PD might be progressing which seemed unlikely in that the change in my pwp seemed to occur "overnight". I can only attribute to someone greater than I to have led me to even think about the difference in manufacturers. As far as I had known, the generics were required to contain the exact active ingredient as the Brand. I began to think...on my own...that perhaps the "ratio"of that generic ingredient could be "slightly off"which for any PD medication could be an important factor. I finally researched all this on the internet, and I was shocked to find how "off"the active ingredient can be, i.e., that the generic manufacturers bioequivalence of a generic can definitely be "off"which can account for a problem in using specific manufacturers of generics. I went through 3 months of agony and heartbreak watching my pwp virtually "out of her mind"...not knowing how to do things she had been able to do..not being able to communicate...it was the most horrible experience I had had throughout my pwp's 16 years of having PD. Most probably, all of you already know about what I have written...but, just on the chance that it could be new "news"for ANYONE was worth my having written this.

Virginia