I have tried both Mirapex and now Neupro. For me there is a big difference. Mirapex was not very effective. My PD is much like yours, soccertese, -- 95% rigidity 5% tremor -- started with a frozen right shoulder.

I'm guessing its the consistent level of delivery 24/7. With Mirapex, I had uneven symptom control. Neupro keeps symptoms under control at all times. Don't get me wrong, I still have PD aspects, but very manageable.

I also take Azilect. I would say its symptom relief is minor at best. For reasons beyond my comprehension, my insurance rates this a Class 1 drug, and charges $15/month copay -- its gotta be a mistake.

C/L works. But for me the effect waxes and wanes throughout a 24 hr period. No "OFF" time, just uneven relief.

To day the least, everybody is going to be different as far as the best drug regimen goes. I kept switching until I found something that works for me.

My MDS gives out a 30 day trial of Neupro if warranted. I tried it and liked it immediately. 6mg dose is very effective.