FAQ/Help |
Calendar |
Search |
Today's Posts |
09-02-2013, 09:30 AM | #1 | ||
|
|||
Magnate
|
https://www.michaeljfox.org/foundati...dopa-conundrum
i find this discussion on developing a better levodopa administration very interesting. i couldn't tolerate agonists so there was no choice but to start C/L, which i did 4 years after diagnosis and taking mirapex for a year before starting C/L. it's amazing after 30 years since C/L came on the market were're still debating starting agonists vs C/L. I see a lot of newly diagnosed pd'ers paying huge copays for azilect and then later adding an agonist and wonder would they be better off physically and financially on C/L? And then add to that how incredibly expensive any new formulation of C/L will be, i haven't seen the projected price of rytary from impax labs, it's a new extended release C/L waiting for FDA approval but wouldn't be surprised if $10/pill. imagine being prescribed that and azilect? |
||
Reply With Quote |
"Thanks for this!" says: |
09-02-2013, 10:09 AM | #2 | |||
|
||||
Member
|
The linked Journal of Parkinson's Disease http://www.journalofparkinsonsdiseas...mans_Blog.html
has some fascinating entries both pessimistic and optimistic. The Brain Stain entry about how amyloid diseases progress through a sort of crystallization was of particular interest to me as it explains a lot and is hopeful. |
|||
Reply With Quote |
09-02-2013, 10:31 AM | #3 | ||
|
|||
Magnate
|
it's on my list of pd sites that i check daily and is one of the most interesting, the section where they interview researchers and give bios has a lot of interesting perspective.
|
||
Reply With Quote |
09-03-2013, 05:08 AM | #4 | ||
|
|||
Member
|
Quote:
DA's like Neupro, are to keep the dyskinesia monster away by delaying the start of C/L. At least, that's how I see it. No disagreement about the copays. |
||
Reply With Quote |
"Thanks for this!" says: | Tupelo3 (09-03-2013) |
09-03-2013, 07:27 AM | #5 | ||
|
|||
Member
|
Quote:
I also agree with you and Gerry that JPD is a great journal and Jon Palfreman has one of the best PD blogs on the internet. |
||
Reply With Quote |
"Thanks for this!" says: | lab rat (09-04-2013), soccertese (09-03-2013) |
09-03-2013, 08:08 AM | #6 | ||
|
|||
Magnate
|
1. the first pd'ers who received C/L, i think back in the 1970's, many if not all developed DSK fairly soon, indicating it might correlate to how many years you had pd rather than just C/L
2. high doses of apomorphine may cause DSK, so not just C/L 3. DSK are reduced when the C/L can be delivered continuously as with dudopa or the soon to released extended release C/L rytary, even stalevo. even after duodopa is discontinued and oral C/L, reinstated, dyskinesias don't start up right away, indicating the even C/L DELIVERY modifies neurons some way. hope i got the above correct. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096539/ Immediate-release preparations of levodopa have a half-life of 1–3 h,18 the length of which can be modestly increased by inhibition of peripheral catechol-O-methyltransferase (COMT) using either entacapone or tolcapone.19,20 This nonphysiologic stimulation further disrupts an already unstable striatum and is believed to be the basis for the motor fluctuations seen with chronic levodopa therapy.21,22 In fact, continuous infusion of levodopa has been shown to reduce ‘off ’ time and dyskinesias in patients with PD and motor fluctuations,23–25 and longer-acting dopaminergic drugs, such as dopamine agonists, are associated with dyskinesias to a lesser extent.26,27 These findings have led to the evaluation of long-acting levodopa strategies to treat the motor symptoms of PD.28 ================= i wish i could tolerate agonists, a patch or 1 pill/day would be nice. after 7years on C/L, never had DSK. |
||
Reply With Quote |
09-04-2013, 04:17 AM | #7 | ||
|
|||
Member
|
Quote:
The MDS I go to hands out free samples like candy. |
||
Reply With Quote |
09-04-2013, 09:08 AM | #8 | ||
|
|||
Magnate
|
that's great if it's working for you at what i assume is a very low dose. how well do those patches stay on and any skin irritation? the concept is great, deliver the agonist directly into the blood and avoid the digestive system. do you wear a patch at night?
|
||
Reply With Quote |
09-06-2013, 05:13 AM | #9 | ||
|
|||
Member
|
Quote:
I have no side effects at 6mg. Can go higher, but side effects could appear. The OVERWHELMING advantage is continuous delivery. Co pay is high -- but well worth it. A HUGE improvement vs. Mirapex. |
||
Reply With Quote |
"Thanks for this!" says: | soccertese (09-06-2013), Tupelo3 (09-06-2013) |
09-06-2013, 07:21 AM | #10 | ||
|
|||
Magnate
|
MIRAPEX DOSE, side affects?
your neupro dose, cost, side affects? taking anything else? i have a friend paying thru the nose for azilect to add to their mirapex for a minor improvement, maybe it might be worth trying neupro. and in the final analysis, would cheap old C/L work just as well? |
||
Reply With Quote |
"Thanks for this!" says: | Tupelo3 (09-06-2013) |
Reply |
|
|
Similar Threads | ||||
Thread | Forum | |||
on Palfreman’s Blog, comment on nigrostriatal pathology and gene therapy trials | Parkinson's Disease | |||
Doctor Conundrum | Reflex Sympathetic Dystrophy (RSD and CRPS) | |||
I'm in a conundrum | The Stumble Inn | |||
Mrs D and all... I've a conundrum or a puzzle? | Medications & Treatments |